José M. da Costa Cruz, Brazilian microbiologist and immunologist (Belém 24 February 1894 – Rio de Janeiro 29 October 1940)

Showed the toxigenic capacity of diphtheria bacillus depended on culture medium (not published)

Modified Ramon culture medium for production of diphtheric toxin 

Demonstrated the phage sensitivity to oligodynamic action

Performed important researches about phages that were cited in classical works of D’ Herelle

Prepared Bacteriophagina, an anti-dysenteric product (1920s)

Established an agglutination optimum

Étude de l’optimum d’agglutination. C.R. Soc. Biol. 100(11):1932, 1929

Proved the relationship between bacterial multiplication and phage power

Influence de la concentration des bacteries sur la production du bacteriophage. C.R. Soc. Biol. 92:310-1, 1925

First to study the immune interference in bacterial lysis by phage (before Hauduroy)

Action anti-lityque des sérums anti-bacterien dans la lyse par le bacteriophage. C.R. Soc. Biol. 93(28):875, 1925 & 95(29):1006, 1926

Action du sérum anti-bactérien dans la lyse par bacteriophage. C.R. Soc. Biol. 95(36):1457, 1926

Observed the destructive action of yellow fever virus on complement system and developed a complement-fixation reaction for diagnosing it (Costa Cruz reaction)

Teneur du sérum em alexine dans la fievre jaune. C.R. Soc. Biol. 101:948, 1929

Diagnostic de la fievre jaune par le dosage de l’alexine. C.R. Soc. Biol. 104(21):668, 1929

Established the role of administration of active phages by via oral into evolution of bacillary dysentery (1924)

Le traitement des dysentéries bacillaires par le bacteriophage. C.R. Soc. Biol. 92:845-6, 1925

Showed the solubility of bacteriophages in the presence of electrolytes

Sur la nature du bacteriophage. Influence des electrolytes. C.R. Soc. Biol. 89:759-62, 1923

Sur l’influence des electrolytes dans la lyse par le bacterióphage. C.R. Soc. Biol. 91:236, 1924

With H.A. Penna. Sur um nouveau constituant de l’alexine. C.R. Soc. Biol. 104(21):668, 1939

Described species Mycobacterium fortuitum 

Mycobacterium fortuitum: a new acid-fast bacillus pathogenic for man. Acta Med. Rio de Janeiro 1:297-301, 1938

Costa-Cruz phenomenon

Sur le mécanisme de l’action anti-lityque du sérum anti-bacterien dans la lyse par le bacteriophage. C.R. Soc. Biol. 91:840-2, 1924

His studies about phages are condensed in a paper

O bacteriófago, suas propriedades, sua natureza e sua ação terapêutica. O Hospital 18(2):171, 1940

LINKS  

http://aparaciencias.org/vol-2.1/07_Jose_da_Costa_CruzAA.pdf