Gastão Rosenfeld, Hungarian-born Jewish Brazilian biomedical scientist (Budapest 26 July 1912 – São Paulo 15 July 1990)

From Hungarian father and Egyptian mother from French ascent

ACHIEVEMENTS

Studied properties of natural toxins

Authored many important studies on physiopathology of poisoning by animals 

With F.G. de Langlada. Difference between lethal doses of toxic substances injected intravenously and intraarterially. Mem. Inst. Butantan 31:185, 1964

A new method for studying Hematozoa

Novo método para pesquisa de hematozoários. Rev. Assoc. Paul. Med. 18:306, 1941

Developed Rosenfeld staining, a rapid pan-chromic staining for blood smears combining May-Grunwald and Giemsa methods

Método rápido de coloração de esfregaços de sangue. Noções práticas sobre corantes pancrômico e estudo de diversos fatores. Mem. Inst. Butantan 20:315-28, 1947

Corante pancrômico para a hematologia e citologia clínica: nova combinação dos componentes do May-Grunwald e do Giemnsa num só corante de emprego rápido. Mem. Inst. Butantan 20:329-334, 1947

Co-discovered bradykinin (1949)

With M. Rocha e Silva & W.T. Beraldo. Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin. Am. J. Physiol. 156:261-73, 1949

With L.A.P. de Camargo. Retração normal do coágulo sanguíneo. Coeficiente de correção e índice de retração. Rev. Bras. Biol. 9:510, 1949

With B. Janszky & A.T. Leão. Método de investigação da ação de drogas sobre a coagulabilidade do sangue “in vivo”. Seara Med. 6:515, 1951

Introduced a new treatment for chronic leukemia using personal control of maintenance dosis

Considerations on the classification frequence and treatment of leukemia. Acta Unio Int. Contra Cancrum 11(3):313-7, 1955

With O.G. Hampe & E.M. Kélen. Coagulant and fibrinolytic activity of animal venoms: determination of coagulant and fibrinolytic index of different species. Mem. Inst. Butantan 29:143-63, 1959 

With E.M.A. Kelen & F. Nudel. Hemolytic activity of animal venoms. I. Classification in different types and activities. Mem. Inst. Butantan 30:117, 1960-2

With L. Hoehne. Studies of comparative hematology (Cerdocyon thous azarae, Bradypus tridactylus, Myrmecophaga tridactyla, Tamandua tetradactyla, domestic dog) 1953-4

Described in detail Rosenfeld neurotoxic facies or myasthenic facies, a pathognomonic sign of the bite by a snake with neurotoxic venom (1960s)

Developed a modified standard technique for determining coagulation time

Técnica padrão da determinação do tempo de coagulação (modificado). J. Bras. Med. 7:695-711, 1965 

With W. Beçak & M.A.R. Barros. Método fotométrico para medição quantitativa de cromossomos (1965)

Described hementerin, an anticoagulant of leech Haementeria lutzi

With Eva M. A. Kélen. Fibrinogenolytic substance (hementerin) of Brazilian blood-sucking leeches (Haementeria lutzi Pinto 1920). Haemostasis 4(1): 51-64, 1975

Paper in Science

With B. Janszky. The accelerating effect of calcium on the fibrinogen-fibrin transformation. Science 116:36-7, 1952