Adolfo Max Rothschild, Jewish Brazilian pharmacologist (São Paulo 09 September 1926 – Ribeirão Preto, São Paulo State 10 April 2009)

Established the role of cellular energetic metabolism in histamine release

With I. Vugman & M. Rocha e Silva. Metabolic studies on the release of the histamine by compound 48/80 in the rat diaphragm. Biochem. Pharmacol. 7:248-55, 1961

Developed methods and techniques for studying histamine release

With M. Rocha e Silva. Experimental design for bioassay of a material inducing strong tachyphylactic effect (anaphylatoxin). Br. J. Pharmacol. Chemother. 11(3):252-62, 1956  

Demonstrated the importance of the experimental use of cellulose sulfate as a depletor of the bradykinin precursor

With Z. Rothschild & A.T. Rosa. Cellulose sulfate as plasminogen activator in rat plasma, an activator of the kinin releasing system. Bol. Fac. Farm. Odontol. Ribeirão Preto 5(1):3-19, 1968

With A. Castania. Endotoxin shock in dogs pretreated with cellulose sulfate, an agent causing partial plasma kininogen depletion. J. Pharmac. Pharmacol. 20(1):77-8, 1968

Some pharmacodynamic Properties of cellulose sulfate, a kininogen-depleting agent in the rat. Brit. J. Pharmacol. Chemother. 33(3):501-12, 1968 

Demonstrated the relevance of bradykinin release in mediating adrenaline-induced pulmonary edema

With A. Castania. Contribution to vasopressor and plasma kininogen changes towards acute adrenaline pulmonar edema in the rat. Naunyn-Schmiedberg’s Arch. Pharmacol. 295:177-81, 1976

Showed and contributed to knowledge of reversible swelling of mast cells granules

With E.L. Tamburus. Reversible swelling evoked by epinephrine, 8-bromo-cyclic-3’,5’guanosine monophosphate and feeding in the mast cells of the rat. Biochem. Pharmacol. 30(5):469-79, 1981

With E.L. Gomes & M.A. Rossi. Reversible rat mesenteric mast cell swelling caused by vagal stimulation or sham-feeding. Agents Actions 34:295-301, 1991

With E.L. Gomes & M.A. Rossi. Parasympathetically-mediated swelling of mast cell granules during feeding. Agents Actions Suppl. 36:78-86, 1992 

Papers in Nature

With M.P.de Oliveira. Effects of catecholamines on rat mesentery mast cells. Nature 218:382-4, 1968

With L.A. Gascón. Sulphuric esters of polysaccharides as activators of a bradykinin-forming system in plasma. Nature 212:1364, 1966

With M. Rocha e Silva. Anaphylatoxin, histamine depletion and skin reactions in the rat. Nature 175:987-8, 1955

HONORS

Visiting Professor, College of Medicine, Tel Aviv University (1969)