Alejandro Constantino Paladini, Argentine biochemist (Buenos Aires 19 April 1919 – 15 September 2012)

With L.F. Leloir identified and isolated 2 new coenzymes (1948)

With R. Caputto, C.E. Cardini and L.F. Leloir discovered sugar nucleotides, determined its chemical nature and showed that play a key role in sugar interconversion and polysaccharides synthesis (1948)

Established the structure of antibiotic tyrocidine A (1951-2)

With J.M. Dellacha, J.A. Santomé & M.A. Enero isolated and characterized ovine growth hormone (1970)

With J. A. Santomé & J.M. Dellacha elucidated amino acid sequence and the structure of bovine growth hormone (1973)

With R.D. Conde, J.A. Santomé & J.M. Dellacha isolated, characterized and purified equine growth hormone (1973)

With Pena, Medina, Novas & De Robertis discovered N-butyl-β-carboline-3-carboxylate that binds to cerebral benzodiazepine receptors (1986) 

With J.H. Medina, H. Viola & C. Wolfman proposed flavonoids as a new family of benzodiazepine receptor ligands (1997)

METHODS/TECHNIQUES  

With Morris developed a method for determination of angiotensin in blood

With E. Braun-Menendez & O.A. Scornik. Further improvements on a method for the estimation of angiotensin in blood. Acta Physiol. Lat. Am. 10:64-7, 1960 

With N. Gonzalez Cadavid. Automatic amino acid analysis: reagent and instrumental improvements. Anal. Biochem. 9:170-4, 1964  

Eponym of Paladini-Leloir solvent

PATENTS

With B.K. Cassels, F.J. Dajas, J.H. Medina & R.H. Silveira. Flavonoid and biflavonoid derivatives, their pharmaceutical compositions, their anxiolytic activity    US5756538 (1998) & US 6004998 (1999)

With J.H. Medina. Use of nitroflavonoids for the treatment of anxiety. US6080780 (2000)