Maximiliano Ruiz Castañeda
Maximiliano Ruiz Castañeda, Mexican biomedical scientist (Acambay, Mexico State 05 December 1896 – Ciudad de Mexico 01 October 1992) With H. Zinsser & H. Mooser identified murine typhus (Rickettsia typhi) in 1930 With C. Carrillo Cardenas. A new approach to treatment of brucellosis. Am. J. Med. Sci. 226(5):504-8, 1953 METHODS/TECHNIQUES Proposed the differential stain for the detection of rickettsiae and chlamydial elementary bodies in tissue samples A new stain for rickettsia bodies. J. Infect. Dis. 47(5):416-7, 1930 With H. Zinsser. Method of obtaining large amounts of Rickettsia prowazeki by x-ray radiation of rats. Exper. Biol. Med. 29(7), 1932 Perfected a vaccine for exanthematic typhus known as Castañeda vaccine (1938) With R. Silva. A rapid bedside diagnostic test in typhus (1940) Developed Ruiz Castañeda medium With R. Tovar & R. Velez. Studies on brucellosis in Mexico. Comparative study of various diagnostic tests and classification of the isolate bacteria. J. Infect. Dis. 70:97-102, 1942 Selective agglutination, a possible substitute for the absorptive test in the classification of Brucella, Salmonella or their antisera (1942) Developed bivalent vaccine for typhus (1944) A serum agglutination technique in slides (1945) Developed Castañeda rapid slide agglutination test for brucellosis A practical method for routine blood culture in brucellosis. Proc. Soc. Exper. Biol. Med. 64:114-5, 1947 Developed surface fixation method, forerunner of immunoblot Surface fixation. A new method of detecting certain immunological reactions. Proc. Exp. Biol. Med. 73(1):46-9, 1950 Improved apparatus for the isolation of Brucella and Salmonella by hemoculture. Bull. World Health Organ. 14(4):795-6, 1956 With M.A. de los Corvera & J. Olarte. A new medium for the isolation of Brucella and Salmonella by blood culture. Bull. World Health Organ. 14(4):797, 1956 An improved outfit for the isolation of Brucella, Salmonella, etc by blood culture (1957) Rapid method for investigating the concentration of urea in the blood. Rev. Med. Hosp. Gen. 28(5): 369-71, 1965 Simplification of methods for the study of beta hemolytic Streptococcus in faryngeal exudates. Bol. Med. Hosp. Infant. Mex. 33(2):481-5, 1976 With Y. Naranjo. Rapid test for diagnosis of syphilis by means of the surface fixation method using as antigens VDRL and Treponema pallidum (strain Nichols). Arch. Invest. Mex. 9(4):559-64, 1978 A simple test for detection of specific and unspecific immunological reactions in cancer. Arch. Invest. Mex. 11(1):83-93, 1980 With A. Lopez Merino & F. Ruiz-Reyes. Rapid test for the diagnosis of onchocercosis. Bol. Med. Hosp. Inf. Mexico 39(4):265-7, 1982 Discovered an autovaccine procedure for allergies Papers in top journals With H. Zinsser. Active and passive immunization in typhus fever. Proc. Natl. Acad. Sci. USA 20 (1):9-11, 1934 Bivalent typhus vaccine of high immunizing value. Science 96(2491):304, 1942 HONORS Honorary Fellow, American Society of Immunology (1944) Visiting Professor, Tulane University (1945-6) Fellow, New York Academy of Sciences (1955) Medicine & Physiology Nobel Prize nominee (1965) EPONYMY Castañeda bottle for culture of Brucella Ruiz Castañeda biphasic blood culture Zinsser-Ruiz Castañeda method Ruiz Castañeda reaction for typhoid (similar to Huddleson reaction) Ruiz Castañeda reaction for brucellosis Ruiz Castañeda staining for Rickettsiae (1930)
Mauricio Rocha e Silva
Maurício Oscar da Rocha e Silva, Brazilian pharmacologist (Rio de Janeiro 19 September 1910 –São Paulo 19 December 1983) Authored about 300 papers and 7 books Co-authored with J. Garcia Leme & H. Rothschild Chemical Mediators of the acute inflammatory reaction edited by Pergamon Press in 1972 and worldwide used With O.G. Bier noticed that the hemolysis is inhibited by hypertonic concentrations of NaCl (1935) Demonstrated that role of histamine in the permeability of inflammation With O.G. Bier. Histamine as the primary cause of the increased capillary permeability in inflammation (1939) First stated the proteolytic theory of histamine release (1938) Proved the heparin liberation in distinct types of shock With S.O. Andrade & L.B. Teixeira. Coagulation defect in the shocks produced by trypsin peptone and ascaris extracts. Exp. Med. Surg. 4:260, 1946 With E.A. Scroggie, E. Fidlar & L.B. Jaques. Liberation of histamine and heparin by peptone from isolated dog’s liver. Proc. Soc. Exp. Biol. Med. 64:141, 1947 Discovered bradykinin With W.T. Beraldo. Um novo principio autofarmacológico (bradicinina) liberado sob a ação de veneno de cobras e de tripsina. Ciência e Cult. 1:32-5, 1949 With G. Rosenfeld & W.T. Beraldo. Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin. Am. J. Physiol. 156:261-73, 1949 Obtained the pure form of bradykinin With S.O. Andrade. Purification of bradykinin by ion-exchange chromatography. Biochem. J. 64:701-5, 1956 First report of an epidemics of bovine cattle photosensibilization in the world caused by a plant besides elucidating this disease (Andradina, São Paulo State 1938) Fotossensibilização em bovinos. “A peste das queimadas”, doença produzida pelo Holocalyx glaziovii. Arq. Inst. Biol. (1940) With A.M. Rothschild & I. Vugman established the role of cellular energetic metabolism in histamine release Papers in renowned journals With A.M. Rothschild. Anaphylatoxin, histamine depletion and skin reactions in the rat. Nature 175 (4466):987-8, 1955 With O. Bier & M. Aronson. Histamine release by anaphylatoxin. Nature 168:465-6, 1951 With W.T. Beraldo. Effect of cations upon recovery of the guinea pig gut from inhibition by antihistaminics. Science 108 (2798):162-3, 1948 With S.O. Andrade & R.M. Teixeira. Fibrinolysis in peptone and anaphylatic shock in the dog. Nature 157:801, 1946 With S.O. Andrade. Antagonism between heparin and plasma trypsin. Science 102:670, 1945 METHODS/TECHNIQUES Method of assay of bradykinin upon the guinea pig gut. Acta Physiol. Lat. Am. 2(4):238-50, 1952 Developed an assay using Latin square design for histamine releasing action of anaphylatoxin With A.M. Rothschild. Experimental design for bioassay of a material inducing strong tachyphylactic effect (anaphylatoxin). Br. J. Pharmacol. Chemother. 11(3):252-62, 1956 Concerning the theory of receptors in pharmacology. A rational method of estimation of p Aτ. Arch. Int. Pharmacodyn. 118:74, 1959 With A. Antonio described perfusion method of rat paw subcutaneous tissue in Med. Exp. 3:371, 1960 Proposed an indirect method for calculating pAx based on the ratios between the slopes of reciprocal dose-effect regressions obtained in presence and absence of the antagonist With C.R. Diniz, I. F. de Carvalho & J. Ryan. A micromethod for the determination of bradykininogen in blood plasma. Nature 192:1194-5, 1961 Developed a technique for detecting histamine in nano-quantities With I. Vugman. Biological determination of histamine in living tissues and body fluids. In: Rocha e Silva, M. (editor). Handbook of experimental pharmacology, vol 18(1), 1966 With H. O. Schild developed the isolated diaphragm of guinea pig technique Modified M. Rose device for myxomicetes rheotropism With A. Dreyfus. Sobre certos aspectos do hygrotropismo das larvas de Megaselia scalaris Loew. Rev. Biol. Hyg. 6(1):36-8, 1935 HONORS Medicine & Physiology Nobel Prize nominee
Matias Gonçalves de Oliveira Roxo
Matias Gonçalves de Oliveira Roxo, Brazilian geologist and paleontologist (Rio de Janeiro 21 April 1885 – Rio de Janeiro 02 August 1954) Authored 67 works DESCRIBED FOSSIL TAXA Mollusca Artemon andradai 1940 Aylacostoma septecincta 1937 Aylacostoma woodwardi 1924 Biomphalaria bourguyi 1924 Ecuadoria minor 1937 Neritina etheridgi 1924 Brachiopoda Schizocrania rectangularis 1926 Vertebrata Alligator parahybensis 1929 (Reptilia) Lepidotes piauhyensis 1936 with Lofgren (Pisces) Roxochampsa paulistanus 1936 (Reptilia) Trigodonops lopesi 1921 (Mammalia) HONORS (Fossil) Roxoa Mendes 1952 (Mollusca) Roxochelys Price 1953 (Reptilia) Roxochampsa Pinheiro, Pereira, Souza, Brum, Lopes, Machado, Bergqvist & Simbras 2018 (Reptilia)
Mario Rigatto
Mário Rigatto, Brazilian cardiopneumologist (Porto Alegre 12 January 1930 – Porto Alegre 17 January 2000) Authored 380 publications DEVELOPED METHODS With D. Martínez, R.P. Low, R.P. Pereira, C.A.M. Gottschall & M.L. Leão. Sistema de arquivo e processamento de provas de função pulmonar por computador. J. Bras. Pneumol. 6(4):162, 1981 With E.O. Andrade, G.R. Rocha & D. Martínez. Método simplificado de detecção precoce de obstrução das vias aéreas em fumantes (1980) Determination of cardiac output using nitrous oxide in closed circuit. Arq. Bras. Cardiol. 21 Suppl 1:1-21, 1968 Pulmonary recirculation: measurements at rest during exercise by a method which estimates the concentration of the test gas in the mixed venous blood. J. Physiol. 191(2):98-9, 1967 With G.M. Rigatto & A.P. Fishman. Determination of pulmonary capillary blood flow in man. Circ. Res. 9(4):945-62, 1961 With A.P. Fishman. Aluminium decompression chamber and body pletismograph. J. Appl. Physiol. 16:391-2, 1961 Papers in The Lancet With E.A. Oppenheimer & C.M. Fletcher. Airways obstruction before and after isoprenaline, histamine and presnisolone in patients with chronic obstructive bronchitis. Lancet 1 (7542):552-7, 1968 With E.A.Oppenheimer, S.W. Kuper & D. Shortridge. Cytological examination of the sputum. Lancet 2 (7524):1001-2, 1967 HONOURS Special Citation Award, American Cancer Society (1987) Marquis Who’s Who in the World (1971, 1975 e 1999) Visiting Professor, Hammersmith Hospital (1966 & 1991), Karolinska Institut (1966), McMaster Hospital and Pennsylvannia (1991) Genus Rigattoptera 1996 (Fossil Neoptera)
Marilia Regali
Marilia da Silva Pares Regali, Brazilian micropaleontologist and palynologist (Mogi Mirim, São Paulo State 03 January 1930 – São Paulo State 01 June 2018) DESCRIBED FOSSIL TAXA Genera Alaticolpites 1974 with Uesugui & Santos Bahiaporites 1974 with Uesugui & Santos Complicatisaccus 1987 Echitricolpites 1974 with Uesugui & Santos Mystheria 1986 with Sarjeant Psiladicolpites 1989 Psilaperiporites 1974 with Uesugi & Santos Psilastephanoporites 1974 with Uesugui & Santos Scabraperiporites 1974 with Uesugui & Santos Sergipea 1974 with Uesugui & Santos Tricornites 1974 with Uesugui & Santos Tucanopollis 1989 Species Alaticolpites limai 1974 with Uesugui & Santos Apectodinium caiobense 1974 with Uesugui & Santos Aquilapollenites magnus 1974 with Uesugui & Santos Areoligera espiritosantensis 1974 with Uesugui & Santos Bahiaporites reticularis 1974 with Uesugui & Santos Cicatricosisporites cristatus 1974 with Uesugui & Santos Cingulatisporites verrucatus 1974 with Uesugui & Santos Clavatricolpites daemoni 1974 with Uesugui & Santos Clavatriletes disparilis 1974 with Uesugui & Santos Cleitosphaeridium bahiaense 1974 with Uesugui & Santos Complicatisaccus cearensis 1987 Cricotriporites almadaensis 1974 with Uesugui & Santos Crotonipollis microclavatus 1974 with Uesugui & Santos Echitricolpites communis 1974 with Uesugui & Santos Echitricolpites solaris 1974 with Uesugui & Santos Echitricolporites minutus 1974 with Uesugui & Santos Echitriletes muelleri 1974 with Uesugui & Santos Elateropollenites bicornis 1989 Elateropollenites dissimilis 1989 Elateropollenites praecursor 1989 with Viana Ephedripites pentacostatus 1974 with Uesugui & Santos Ephedripites subtilis 1974 with Uesugui & Santos Equisetosporites undulatus Fenestrites gemmatus 1974 with Uesugui & Santos Foveomonosulcites elegans Foveotriletes ornatus 1974 with Uesugui & Santos Fusiformisporites polyhedricus 1974 with Uesugui & Santos Gnetaceaepollenites concisus 1989 Gnetaceaepollenites crassipolii 1974 with Uesugui & Santos Gnetaceaepollenites pentaplicatus 1989 Gnetaceaepollenites undulatus 1974 with Uesugui & Santos Hystrichosphaeridium sergipensis 1974 with Uesugui & Santos Impletosphaeridium (Operculodinium) bahiaense 1974 Inaperturopollenites crisopolensis 1974 with Uesugui & Santos Inaperturopollenites curvimuratus 1974 with Uesugui & Santos Inaperturopollenites simplex 1974 with Uesugui & Santos Mystheria oleopotrix 1986 with Sarjeant Nodosisporites baculatus 1974 with Uesugui & Santos Parvisaccites minimus 1987 Pentaspis lammonsi 2000 with Pedrão & Barrilari Pentaspis simplex 2000 with Pedrão & Barrilari Psiladicolpites comptus 1989 Psiladicolpites laevis 1989 Psiladicolpites papillatus 1989 Psilamonocolpites minutus Psilaperiporites minimus 1974 with Uesugui & Santos Psilaperiporites robustus 1974 with Uesugui & Santos Psilastephanocolporites fissilis 1974 with Uesugui & Santos Psilastephanocolporites variabilis 1974 with Uesugui & Santos Psilastephanocolporites tesseroporus 1974 with Uesugui & Santos Psilastephanoporites brasiliensis 1974 with Uesugui & Santos Psilastephanoporites stellatus 1974 with Uesugui & Santos Psilatricolporites divisus 1974 with Uesugui & Santos Psilatricolporites maculosus 1974 with Uesugui & Santos Psilatricolporites papilioniformis 1974 with Uesugui & Santos Regalipollenites amphoriformis 1974 with Uesugui & Santos Retistephanocolpites gracilis 1974 with Uesugui & Santos Retitricolpites amapaensis 1974 with Uesugui & Santos Retitricolporites amazonensis 1974 with Uesugui & Santos Retitricolporites belmontensis 1974 with Uesugui & Santos Retritricolporites mirabilis 1974 with Uesugui & Santos Retitricolporites perpusillus 1974 with Uesugui & Santos Retitricolporites quadrosis 1974 with Uesugui & Santos Retitriletes sommeri 1974 with Uesugui & Santos Rugubivesiculites bahiasulensis 1989 Scabraperiporites nativensis 1974 with Uesugui & Santos Sergipea crassiverrucata 1987 Sergipea naviformis 1974 1974 with Uesugui & Santos Sergipea simplex 1987 Sergipea tenuiverrucata 1987 Sergipea variverrucata 1987 Spiniferites aracajuensis 1974 with Uesugui & Santos Spiniferites maranhensis 1974 with Uesugui & Santos Steevesipollenites alatiformis 1974 with Uesugui & Santos Steevesipollenites duplibaculum 1974 with Uesugui & Santos Steevesipollenites giganteus 1974 with Uesugui & Santos Striatricolpites reticulatus 1974 with Uesugui & Santos Surculosphaeridium alagoense 1974 with Uesugi & Santos Syncolporites triangularis 1974 with Uesugui & Santos Thalassiphora salvadorense 1974 with Uesugui & Santos Tricornites elongatus 1974 with Uesugui & Santos Trisectoris regulatus 1974 with Uesugui & Santos Tuberculodinium paraense 1974 with Uesugui & Santos Tucanopollis crisopolensis 1974 with Uesugui & Santos Verrutriporites asymmetricus 1974 with Uesugui & Santos Vitreisporites microrugulatus 1987 Vitreisporites pustulosus 1987 HONORS Regalipollenites Lima 1980 (Fossil Sporae)
Mariano Eduardo de Rivero
Mariano Eduardo de Rivero y Ustariz, Peruvian naturalist, chemist and archaeologist (Arequipa 22 October 1798 – Paris 06 November 1857) Authored at least 33 scientific works ACHIEVEMENTS Discovered mineral humboldtine (1821) Note sur une combination de l’acide oxalique avec le fer trouve a Kolowsereux, prés Berlin em Boheme. Ann. Chim. Phys. 18:207-10, 1821 Proposed employing ammoniac in aqueous solution as alternate to mercuric chloride in silver extraction Sobre el beneficio de los metals de plata mediante la amalgamación (1822) Described 3 new mineral species in Nueva Granada (e.g. gay-lussite) With J.B. Boussingault. Tres species nuevas minerales de la Nueva Granada (1824) With J.J. Tschudi established interparietal suture (os incae) as an Inca trait in Antiguedades Peruanas (1851) WORKS TRANSLATED TO ENGLISH AND FRENCH Memoire sur la nature et l’usage du guane au Pérou (1827) Memorial de Ciencias Naturales y de Industria Nacional y Extranjera (1827-9) with N. Fernandez de Pierola Antiguedades Peruanas (1851) with J. J. Tschudi OFFICES Governor, Junín Department (1846-8) and Moquega Department