Lourival Domingos Possani
Lourival Domingos Possani, Brazilian-born Mexican toxicologist (Santo Angelo, Rio Grande do Sul State 09 July 1939 – Authored 500 publications (with about 19,700 citations by Google Scholar, about 17,000 by ResearchGate and about16,600 by Research.com) Described a number of novel toxins form scorpions, reptiles, molluscs, spiders and wasps Described the toxic venom peptides that affect the function of ion channels of excitable cells First to report peptides that block potassium (K+) channels (noxiustoxin 1986 and ergtoxin from Centruroides noxius) Found peptide toxins with immune-modulatory function and that with antibiotic and antiparasitic activity Other peptides with interesting biological activities such as specific toxins for insects and crustaceans With F.Z. Zamudio discovered hadrurine (from Hadrurus gertschi) and scorpine (from Pandinus imperator) with microbicide activity (2000) Isolated and characterized a peptide with antiepileptic activity from Centruroides limpidus limpidus (1994) Designed and synthesized about a hundred peptides OTHER CONTRIBUTIONS With M.U. Naseem, E. Carcamo Noriega, J. Borrego, T.G. Szanto, F.Z. Zamudio, G. Delgado-Prudencio & G. Panyi. Cm28, a scorpion toxin having a unique primary structure, inhibits KV12 and KV13 with high affinity. J. Gen. Physiol. 154(8), 2022 With M. Benard Valle, E.E. Neri-Castro, M.F. Yañez-Mendoza, B. Lomonte, A. Olvera, F. Zamudio, R. Restano-Cassulini, E. Jimenez-Ferrer & A. Alagon. Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: identification of the first lethal multimeric neurotoxin in coral snake venom. J. Proteom. 225:103863, 2020 With F. Caliskan, V. Quintero-Hernandez, R. Restano-Cassulini, F.I. Coronas-Valderrama & G. Corzo. Molecular cloning and biochemical characterization of the first Na+- channel alpha-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom. Biochimie 95:1216-22, 2013 With L. Riano-Umbarila, V.R. Juarez-Gonzalez, T. Olamendi-Portugal, M. Ortiz-Leon & B. Becerril. A strategy for generation of specific human antibodies by directed evolution and phage dusplay. Febs J. 272:2591-01, 2005 With A. Shalabi, F. Zamudio, X. Wu, A, Scaloni & M.L. Villereal. Tetrapandins, a new class of scorpion toxins that specifically inhibit store-operated calcium entry in HEK-293 cells. J. Biol. Chem. 279:1040-9, 2004 With M. Corona, F.V. Coronas, E. Merino, B. Becerril, R. Gutierrez, S. Rebolledo-Antunez & D.E. Garcia. A novel class of peptide found in scorpion venom with depressant effects in peripheral and central nervous system of the rat. Biochim. Biophys. Acta Prot. Proteom. 1649:58-67, 2003 With F. Gómez Lagunas & T. Olamendi Portugal. Block of Shaker B K+ channels by Pi1, a novel class of scorpion toxin. FEBS Lett. 400:197-200, 1997 PAPERS IN TOP JOURNALS With E. Carcamo-Noriega, S. Sathyamoorthi, S. Banerjee, E. Gnanamani, E. Mendoza Trujillo, D. Mata-Espinosa Montserrat, R. Hernandez Pardo, J.I. Veytia Bucheli & R.N. Zare. 1,4-benzoquinone antmicrobial agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion venom. Proceed. Natl. Acad. Sci. 116(26):12642-7, 2019 Antivenom for scorpion sting. The Lancet 355:67, 2000 With M.M. Altamirano, C. Garcia & A.R. Fersht. Oxidative refolding chromatography: folding of the scorpion toxin Cn5. Nature Biotechnol. 17:187-91, 1999 With E. Carbone, E. Wanke, G. Prestipino & A. Maelicke. Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin. Nature 296:90-1, 1982 With R. Banerjee, C. Balny & P. Douzou. Oxidation of haemoglobin by oxygen in light: possible role of singlet oxygen. Nature 226:861-2, 1970 PATENTS With R.N. Zare, J.I. Veytia Bucheli, E.N. Carcamo Noriega, G. Elumalai, S. Sathyamoorthi, S. Banerjee & R.E. Hernandez Pando. Scorpion venom benzoquinone derivative and uses thereof US20210214303A1 EP3801765A1 CN112512635A (2021) WO2019231735A1 (2019) With M.V. Prates, G.A. Joanitti, C. Bloch Jr., S.M. de Freitas, G.D. Brand, J.P.C. Fernandes, C.B.F. Mourão, J.A.R.G. Barbosa, E.N.F. Schwartz, M.R. Mortari, R.M.R. Cassulini & S.G. da Fonseca.Peptídeos inibidores de serinopeptidase modificados de peçonha de escorpião, seu processo de obtenção e uso BR102017013362A2 (2020) With M.M. Pedraza Escalona, G.P. Espino Solis, A. Olvera Rodríguez & H.M. Cardoso Torres. Monoclonal antibodies against the DEC-205 receptor of chicken denditic cells US09951135B2 (2014) & MX346878B (2017) With M.A. Abdel Rahman, A.A.M. Hassan, H. Hotta & M.M. Sarhan. Antiviral agent WO2017126340A1 (2017) With V. Quintero, L. Gonzalez, J.M. Jimenez-Vargas, E. Ortiz, G. Corzo & B. Becerril.Composición farmaceutica de proteinas híbridas recombinantes capaces de generar anticuerpos neutralizantes em contra del veneno de alacranes MX2016002188A (2015) WO2017142388A2 (2017) With B. Becerril Luján, J.N. Arredondo López, I.V. Gómez Ramírez, E.R. Rodríguez Rodríguez, L. Riaño Umbarila, G. Fernandez Taboada & T.C. Olamendi Portugal. Human recombinant antibodies family of variants that neutralize the venom of the main poisonous scorpions MX2015011378A (2015) With I. Arenas Sosa, R. Rodríguez Hernandez, O. Walls Flores & G. Corzo Burguete. Actividad antimicrobiana “in vitro” de la combinación de péptidos antibiocidas de alacrán con antibioticos de uso común MX2015009505A (2015) With E. Ortiz, S. Ramírez Carreto, J.M. Jimenez Vargas & G. Corzo. Péptidos del alacrán Vaejovis punctatus como antibioticos contra Mycobacterium tuberculosis y outras bacterias y levaduras patógenas MX359976B (2015) With P.G. Gurrola Briones, S.P. Salas Castillo, C.V. Ferreira B., Z.S. Varga, G. Panyi & R. Gaspar. Vm23 and Vm24, two scorpion peptides that block human T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats (2012) Europe 07734817.5, US 12/599,978 CN200780053305.7 CA2686216 AU2007353147 Israel202113 Euroasia 200901530 Korea 10-2009-7026000 Brazil (?) Cuba 2009-0194 JP (?) India 7396/DELNP/2009 Singapore 20097395-8 South Africa (2009) PCT (2007) With G. Corzo & F. Garcia. Uso de un péptido antibiotico proveniente del veneno del alacrán Centruroides suffusus suffusus y sus composiciones farmacéuticas obtenidas con antibióticos comerciales MX 343126B (2011) With G. Corzo, G. Estrada, K. Hernandez & B.I. Garcia. Variantes recombinantes de una toxina del veneno del alacrán Centruroides sufussus sufussus para la producción de antivenenos contra el veneno de alacranes del género Centruroides (2011) With A. Alagón C, G. Gurrola, E.V. Grishin, A.V. Lipkin & K.E. Volynski.Immunogen, anti-venom and vaccine against the venom of the Black Widow Spider US (?) EP00980069.9 CA2,397,731 (2002) MX (2010) PCT(2000) UNAM-MX (1999) With G. Gurrola Briones, C.A. Hernandez Aponte & J. Silva Sanchez, Vejovina – un péptido antibiótico (2009) With L. Riaño U & B. Becerril L. Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpion venom US (2008 & 7,381,802 B2 2005) Mexico (2009) With M. Corona, M.C. Garcia, N.A. Valdez, G. Gurrola & B. Becerril. Recombinant immunogens for the generation of antivenoms to the venom of scorpions of the
Lorenzo Raimundo Parodi
Lorenzo Raimundo Parodi, Argentine botanist and agronomist (Pergamino, Buenos Aires Province 23 January 1895 – Buenos Aires 21 April 1966) DESCRIBED PLANTAE TAXA Genera/Subgenera Erianthecium 1943 Gymnachne 1938 Hemimunroa 1937 Microbriza 1981 Oplismenopsis 1937 Thrasyopsis 1946 Pseudosporobolus 1928 Species 128 Others 1 subtribe, 2 subfamilies, 80 varieties and 13 forms HONOURS Parodiodoxa O.E. Schulz 1929 (Brassicaceae) Parodianthus Troncoso 1941 (Verbenaceae) Parodiodendron Hunziker 1969 (Euphorbiaceae) Parodiolyra Soderstrom & Zuloaga 1989 (Poaceae) Parodiophyllochloa Morrone, Denham, Aliscioni & Zuloaga 2008 (Poaceae) Lorenzochloa Reeder & Reeder 1968 (Poaceae) Section Parodiochloa Hubbard 1981 (Poaceae)
Llewellyn Ivor Price
Llewellyn Ivor Price, Brazilian paleontologist (Santa Maria, Rio Grande do Sul State 09 October 1905 – Rio de Janeiro 09 June 1980) Son of American parents Authored over 50 papers DESCRIBED FOSSIL VERTEBRATA TAXA Genera Apodichelys 1954 Araripemys 1973 Araripesaurus 1971 Araripesuchus 1959 Baurusuchus 1945 Candelaria 1947 Itasuchus 1955 Mourasuchus 1964 Peirosaurus 1955 Prionosuchus 1948 Pristiguana 1973 with Estes Protorothyris 1937 Romeria 1937 Roxochelys 1953 Sphagesaurus 1950 Species About 20 HONORS (Fossil) Pricecoris Pinto & Ornellas 1974 (Hemiptera) Pricemys Gaffney, Meylan, Wood, Simmons & Campos 2011 (Reptilia)
Livio Dante Porta
Livio Dante Porta, Argentine locomotive engineer (Paraná, Entre Rios Province 21 March 1922 -Lomas de Zamora, Buenos Aires Province 10 June 2003) Recognized as one of world’s foremost locomotive engineers of 20th century Introduced innovative improvements in steam locomotives Proposed several new designs for steam locomotives (2-10-0, 2-10-10-2) in 1960s and 1970s and the Argentina locomotive (1949) DEVELOPED Lempor, Lemprex and Kylpor exhaust systems or blast pipes GPCS System (Gas Producer Combustion System) 1966 A steam bus (with Gustavo Durán) A modern steam car (1970) OTHER CONTRIBUTIONS / BIBLIOGRAPHY A graphical method of adjustment (1946) Theory of cyclonic combustion in locomotive fireboxes (1961) Bar frame design proposals to avoid twisting at the back end and facilitate maintenance (1969) Guide for connection rod-piston rod calculation: a proposal for the TGS bag (1969) A piston valve design for high temperature steam (1975) A new conception of the compound locomotive (1976) A system for coupling both mallet engine units and its extension to other articulated locomotives (1977) Improvements to the air brake pump (1977) Note sur une nouvelle philosophie dans le traitement des eaux pour chaudieres locomotives (1978) Improving existing shunting engines without structural alterations (1978) A feedwater heating system suitable for S65 and T65 locomotives (1978) A proposed mechanical adhesion improver (1979) A mechanical anti-slipping device for steam electric or diesel locomotives (1979) Steam locomotive boiler water circulation – a first semi-quantitative approach (1979) Note on a proposed dynamic braking for advanced steam locomotives (1980) A new superheater-economiser element for advanced steam locomotive technology (1980) Improvements for hand-driven valve gear reverser of steam locomotives (1981) Dispositif de controle de l’hauteur de la mousse dans les chaudieres a basse pression (1982) Improvements to the steam locomotive air-brake pump (1982) A mechanical slip control device for steam, electric and diesel locomotives (1982) Improvement to the Skinner uniflow steam engine (1983) Supporting pad for tail rods and piston valves (based on the ONO principle) 1983 Bar frame design proposals to avoid “vibrillement” at the back end and facilitate maintenance (1983) Boiler foam height meter (1984) A mechanical anti-slipping device for steam, electric or diesel locomotives (1985) Piston valve design for high temperature steam (1985) Some forms of secondary air nozzles for locomotive type boilers (1985) Some suggestions to improve the gasification efficiency near firebox walls (1986) A simplified approach to locomotive balancing (1990) Canarias, a theory of gas phase combustion (1999) Improvements to the hydrostatic cylinder lubricator PATENTS With D.A. Berkowitz, W.L. Withuhn & C.C. Hamilton. Coal fired steam locomotive US4425763 (1980) CA1183722A (1981) AU7505581A (1981) EP0047510A2 & EP0047510A3 (1981) BR8200084A (1982) A locomotive having solid fuel combustion apparatus GB953391A (1961) EPONYMY Porta on-board water treatment (1969) Porta sectional boiler (1969) Porta-De Leonardis elastic wheel (1983) Hudson-Orrock-Porta formula (1984) Porta compound system for steam locomotives (2000) Porta advanced steam locomotive technology LINKS www.trainweb.org/tusp/porta_biblio.htm
Leonel Plasencia
Leonel Plasencia y Montes, Cuban physician (Madruga, La Habana 05 January 1877 – La Habana 17 January 1923) Established haematological formulae for inflammatory and cancerous processes (1901) Ensayo de una nueva clasificación de los epitelios. Progr. Med. 12:98-104, 1902 Nuevos metodos de coloración de parasitos en la sangre. Rev. Med. Trop. La Habana 3(8):123-6, 1902 Neue methode der farbung von Blutparasiten. Arch. f. Schiffs. u. Tropen-Hyg. 7(7):337, 1903 Una variedad del Strongyloides intestinalis. Rev. Med. Trop. La Habana 9:177-92, 1903 Described the semiological value of eosinophils and established hematological formulas Significación biologica del leucocito de granulación eosinofila (1905) Albuminoscopio para luz artificial (1911) Metodo clinico de investigación del arsenico en la orina. Rev. Med. Cubana (1912) Nuevo indigotimetro. Rev. Med. Cir. La Habana 17(1):1, 1912 Eponym of Plasencia bacillus or Bacillus influenzae motilis (1918)
Kuang Pan
Kuang Pan / Guang Pan, Chinese paleontologist (fl.1962-97) DESCRIBED FOSSIL GENERA Plantae Acerites 1983 Amentostrobus 1983 Bennettidicotis 1983 Casuarinites 1983 Cycadicotis 1983 Filicidicotis 1983 Illicites 1983 Juradicotis 1983 Juramagnolia 1983 Kadsurites 1983 Lianshanus 1983 Liaoningdicotis 1983 Polygalites 1983 Setarites 1983 Sinodicotis 1983 Yanliaoia 1977 HONORS Pankuangia Kimura, Ohana, Zhao & Geng 1994 (Fossil Plantae)