João Consani Perrone
João Consani Perrone, Brazilian biochemist (Passa Quatro, Minas Gerais 22 January 1922 – Rio de Janeiro 20 May 1979) With colleagues the studies about castor bean cake gave them a number of scientific discoveries METHODS Perrone method (chromatographic technique for separation of dinitrophenyl aminoacids) Separation of aminoacids as dinitrophenyl derivatives. Nature 167:513-5, 1951 A new method for chromatographic operating of peptides Um novo método para o funcionamento cromatográfico de peptídeos. Rev. Quim. Ind. 26(300):16, 1957 Developed an industrial process for detoxifying castor bean cake With A. Iachan, G.B. Domont, L.V. Disitzer, V.R.O. Castro, R. Roitman & S.M. Gomes. Contribuição ao estudo da torta de mamona (1966) With A. Iachan. Novo método para a dosagem da prolina e da hidroxiprolina. An. Acad. Bras. Cien. 29(4):XLVI, 1957 With A. Iachan & R. Roitman. A method for the determination of proline and hydroxyproline. An. Acad. Bras. Ciencias 31(1):53-55, 1959 With A. Iachan & L.V. Disitzer. A new method for protein hydrolysis with crystallized oxalic acid. An. Acad. Bras. Ciencias 33(2):169-72, 1961 With G.B. Domont & A. Iachan developed 2 methods for the automatic determination of trypsin activity (1963) With R.A. Moreira. Purification and partial characterization of a lectin from Phaseolus vulgaris L. Plant Physiol. 59:783-7, 1977 PAPERS IN NATURE Separation of aminoacids as dinitrophenyl derivatives. Nature 167:513-5, 1951 With A. Iachan & L.V. Disitzer. Electrophoretic heterogeneity of trypsin. Nature 184:1225-6, 1959 With A. Iachan, L.V. Disitzer & G. B. Domont. Fractionation of trypsin by paper electrophoresis. Nature 203(4090):43-5, 1964 SOME BIBLIOGRAPHY With S. Rosenberg & P.L. Kirk. Amperometric titration of sulphydryl groups. Microgram Analysis. Anal. Chem. 22(9):1186-7, 1950 With W. Hull & P.L. Kirk. Tissue culture studies. V. Analogue for nicotinic acid. Journal Gen. Physiol. 34:75-9, 1950 With A. Neuberger & H.G.B. Slack. The relative metabolic inertia of tendon collagen in the rat. Biochem. J. 49(2):199-204, 1951 With H.M. Muir & A. Neuberger. Further isotopic studies on haemoglobin formation in the rat and rabbit. Biochem. J. 52(1):87-95, 1952 With L.D. Antonaccio. The salting-out curve of human serum. An. Acad. Bras. Ciencias 25(4):459-68, 1953 With A. Iachan & L.A. Moreira Carneiro. Reaction of formaldehyde with aromatic amino acids. I. Reaction with tryptophane. An. Acad. Bras. Ciencias 25:107-28, 1953 Reação do formaldeído com os acidos aminados básicos. II. Reação com a histidina. An. Acad. Bras. Ciencias 27(1):35-4, 1955 Cromatography of peptides in columns of cellulose powder. A preliminary note. An. Acad. Bras. Ciencias 28(4):501-8, 1956 With A. Iachan. Separação cromatográfica de ácidos aminados neutros em colunas de cellulose. An. Acad. Bras. Ciencias 30(2):17, 1958 With L.V. Disitzer & G.B. Domont. The automatic determination of trypsin activity. An. Acad. Bras. Ciencias 36(2):131-5, 1964 Fracionamento eletroforético das proteínas da torta de mamona (1964) Curvas de solubilidade das proteínas da torta da mamona (1964) Destoxicação e desalergenização da torta da mamona (1964) With S.H. Kling, E. Solewicz, M.S.P. Daumas et al. Aproveitamento industrial das folhas de mandioca. Inform. Inst. Nac. Tecnol. 9:13-18, 1976 Os processos hidrolíticos no aproveitamento dos recursos renováveis. Silvicultura 3:23-33, 1977 With D. Parreira & E. Rodrigues. Separação cromatográfica de ácidos aminados em colunas de “Dowex 50” pelo uso de um gradiente de pH. An. Ass. Bras. Quim. 15(1-4):29-32, 19?? With J. G. de Carvalho & V.R. Osorio e Castro. Reaction of glutaraldehyde with human erythrocytes. An. Acad. Bras. Ciencias 52(2):419-26, 1980
João Bosco Prolla
João Bosco Prolla, Brazilian mathematician (24 June 1935- First to establish a vector-valued extension of Bishop’s theorem Enunciated Prolla best approximation theorem in hyperconvex metric spaces in Numer. Funct. Anal. Optimiz. 5:449-55, 1982-3. With L. Nachbin & S. Machado proved that the polynomials of finite type from a real locally convex space into another are dense in the space of all continuous function with the compact open topology Introduced the concept of antisymmetric set in weighted spaces (1971) With R.M. Aron showed that the finite type polynomials on a Banach space are exactly the weakly continuous polynomials (1980) Generalized Von Neumann’s variant of Stone-Weierstrass theorem for continuous functions with range in [0,1] (1992) With M.S. Kashimoto presented a Choquet-Deny type theorem for downward filtering convex sets of continuous functions (2006) Eponym of Prolla-Machado condition
Joviano Pacheco
Joviano Augusto do Amaral Pacheco, Brazilian mine engineer and geologist (Capivari, São Paulo State 31 December 1873 – São Paulo 30 May 1949) Described Roxochelys harrisi 1913 (Fossil Reptilia) Authored Relatório elucidativo do esforço geológico da região compreendida entre o meridiano 4º, rio Itararé e os paralelos 23º34’ e 24º38’. Rev. Inst. Geogr. Geol. 11(4):296-303, HONOURS (Fossil) Pachecoa Harris 1919 (Mollusca) Pachecoia Almeida 1950 (Crustacea)
José Piazza
Giuseppe Piazza, Swiss-born Argentine chemical engineer (Blenio District, Ticino Canton 20 March 1892 – ?) DEVELOPED Methods Generalized the procedure of electric discharges at low pressures Gasometric procedure for determination of solid substances Distillation procedures based on a rotating system of his own invention Contribución al estudio de la destilación fraccionada. Nuevo metodo para la determinación rapida de las curvas de equilibrio entre temperatura y composición del liquido y del vapor (1927) Devices Nuevo motor termico (1938) Destilacción fraccionada con aparatos de contracorrente intensa (1941) (developed a distiller) Piezometro de laboratorio (1942) Electromagnetic rotary viscometer Glass thread microbalance
José Pellegrino
José Pellegrino, Brazilian parasitologist and tropical physician (Passagem de Minas, Minas Gerais State 11 November 1922 – Belo Horizonte 10 February 1977) From Italian parents Authored over 350 papers Described two Diptera species, Lutzomyia ferreirana and L. firmatoi with Barretto & Martins (1956) First report about Chagas disease transmission by blood transfusion Transmissão da doença de Chagas pela transfusão sanguínea. Primeiras comprovações sorológicas de esquizotripanos em doadores e em candidatos a doadores de sangue. Rev. Bras. Med. 6(5):297-301, 1949 Identified 14, 15-epoxi-geranylgeraniol, from fruits oil of Pterodon pubescens which prevents the penetration of cercariae of Schistosoma into the skin of host With M.F. Santos Filho, H.J. Monteiro, B. Gilbert & W.B. Mors. Chemoprophylactic agent in schistosomiasis: 14,15-epoxigeranylgeraniol. Science 157:950-1, 1967. Standardized immunological reactions establishing its value in schistosomiasis epidemiology Técnica de reação intradérmica para diagnóstico da esquistossomose. Rev. Bras. Malariol. Doenças Trop. 9:105-21, 1957 Diagnóstico da esquistossomose pela reação intradérmica. Rev. Bras. Doen. Trop. 9:105, 1957 Developed Kagan-Pellegrino-Memoria technique for preparation of antigens for Schistosoma mansoni With J. G. Kagan & J.M. P. Memória. Studies on the standardization of the intradermal test for the diagnosis of bilharziasis. Amer.J. Trop. Med. Hyg. 10:200-7, 1961 Developed a method for preparation of Schistosoma mansoni antigens employing modified Coca’s solution With J.G. Kagan. Critical review of immunological methods for diagnosis of bilharziasis. Bull. World Health Organization 25:611, 1961 Established technical basis for Chagas disease prophylaxis employing residual action insecticides (i.e. Gammexane or BHC in 1948) independently from Abalos With E. Dias. Alguns ensaios com o “Gammexane” no combate aos transmissores da doença de Chagas no Brasil. Brasil Médico 62:185-91, 1948. Proposed an evolutive and morphological classification of Schistosoma mansoni eggs With G. Gazzinelli & F.J. R. Pinto. Purification and characterization of proteolytic enzyme complex of cercarial extract. Comp. Biochem. Physic. 18(14):689-700, 1966 With B. Gilbert, N. Nunes da Rocha & R. Borojevic. Schistosoma mansoni in vitro transformation of cercarial into schistosomules. Parasitology 64:333, 1972 Identified over 20 drugs with experimental activity on schistosomiasis Proposed cellophane paper model for measuring the papulae intensity in schistosomiasis intradermoreaction With D.G. Macedo. Novo critério de leitura da reação intradérmica na esquistossomose. Rev. Bras. Malar. 8(3):499-509, 1956 PHYTOCHEMISTRY & PARASITOLOGY With W.B. Mors, P.M. Baker, T.C.B. Tomassini, B. Gilbert, N. Katz et al. A atividade anti-helmíntica dos óleos essenciais e de seus componentes químicos. Anais Acad. Bras. Ciencias 44:423-8, 1972 With B. Gilbert & D. Santos Filho. Extract of Enterolobium timbouva Martius, 1837, a penetration stimulant for cercariae of Schistosoma mansoni. Rev. Bras. Pesq. Med. Biol. 4(4-5):315-6, 1971 With B. Gilbert, J.P. Souza, C.C. Fortes, D. Santos Filho, A.P. de Seabra & M. Kitagawa. Chemo prophylactic agents in schistosomiasis. I. Active and inactive terpenes. J. Parasitol. 56:397, 1970 With P.M. Baker, C.C. Fortes, E.G. Fortes, G. Gazzinelli, B. Gilbert, J.N.C. Lopes, T.C.B. Tomassini & W. Vichnewski. Chemoprophylactic agents in schistosomiasis, eremanthine, costunolide, alpha cyclo costunolide and bisabolol. J. Pharm. Pharmacol. 24:853-7, 1972 With B. Gilbert, J.P. de Souza, M. Fasao & A.P. de Seabra. Esquistossomose: proteção contra infecção por terpenóides. Anais Acad. Bras. Ciencias 42:397-400, 1970 (Suppl) With A.V. Pinto, M.C.R. Pinto, B. Gilbert & R.M. Mello. Schistosomiasis mansoni: blockage of cercarial skin penetration by chemical agents: I. Naphthoquinones and derivatives. Trans. Royal Soc. Trop. Med. Hyg. 71:133-5, 1977 OTHER TECHNIQUES/METHODS With L.H. Pereira, T.E. Valadares, R.T. Mello & P.M.Z. Coelho. A new approach for screening prophylactic agents in schistosomiasis. Rev. Inst. Med. Trop. S. Paulo 16:123-6, 1974 With F.J. Ramalho Pinto, G. Gazzinelli, R.E. Howells, T.A. Mota-Santos & E.A. Figueiredo. Schistosoma mansoni: defined system for stepwise transformation of cercariae to schistosomula in vitro. Exp. Parasitol. 36:360-72, 1974 With F.M. Coelho, G. Gazzinelli & L.H. Pereira. Standardization of the Fe59 incorporation method in Biomphalaria glabrata for use in study of the crowding effect. Rev. Inst. Med. Trop. 15(6):417-20, 1973 With N. Katz & A. Chaves. Uma técnica simples para a realização do exame de fezes quantitativo na esquistossomose. Cien. Cult. 24(6):416, 1972 With N. Katz & A. Chaves. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev. Inst. Med. Trop. S. Paulo 14:397-402, 1972 With C.E. Borda. An improved thick-smear for quantitative diagnosis of Schistosoma mansoni infections. Rev. Inst. Med. Trop. S. Paulo 10:71-5, 1971 With J. Faria. The oogram method for the screening of drugs in schistosomiasis mansoni. Amer.J. Trop. Med. Hyg. 14:363-9, 1965 With C.A. Oliveira, J. Faria & A.S. Cunha. New approach to the screening of drugs in chemotherapy of Schistosoma mansoni in mice. Amer. J. Trop. Med. Hyg. 11:201-15, 1962 With A.F. Siqueira. Técnica de perfusão para colheita de Schistosoma mansoni em cobaios experimentalmente infestados. Rev. Bras. Malar. Doen Trop. 8:589-97, 1956 With Rosa M.B. Nunes. Technique for obtaining dried cercariae of Schistosoma mansoni for the preparations of antigens. Rev. Bras. Malariol. Doen. Trop. 8:397-404, 1956 With Z. Brener. Method for isolating schistosome granulomas from mouse liver. J. Parasit. 42:564, 1956 With D.G. Macedo. A simplified method for the concentration of cercariae. J. Parasit. 41:329-30, 1955 Técnica para reação de precipitina no diagnóstico da doença de Chagas com sangue colhido na polpa digital. O Hospital 4:437-41, 1953 Métodos e critérios para a realização de inquéritos sobre doença de Chagas em crianças. J. Pediat. 17(5):224-8, 1952
José Leal Prado
José Leal Prado de Carvalho, Brazilian biochemist (Alfenas, Minas Gerais State 08 September 1918 – São Paulo 11 January 1987) Authored most of his works joint to his wife biochemist Eline Michelet Sant’Anna Prado (1921-2007) ACHIEVEMENTS Discovered metacorticoid hypertension independently of S. Fridman Demonstrated the tissue conversion of angiotensin I to angiotensin II, the first demonstration of the presence of converting enzymes in tissues With E. A. Carlini & Z. Picarelli. Pharmacological activity of hypertension I and its conversion into hypertension II. Bull. Soc. Chim. Biol. 40:1825-34, 1958 Performed important studies on metabolism and release of kinins First described clostripain, a kinin from bacterial origin First obtained urinary kallikrein in pure form With H.B. Nader first to show that the constitution of heparin is heterogeneous with distinct components and molecular weights (1974) With A.C.M. Paiva & T.B. Paiva. Non-identity between pepsitensin and hypertension revealed by paper electrophoresis. Science 120:611, 1954 Isolated and characterized glycyl-bradykinin from wasp venom With J. Ribeiro do Valle developed a method or test for pregnandiol (Leal-Valle method) and proposed a model of mice cage described in Ciencia & Cultura number 1, 1949 DID YOU KNOW? Invited to a position in H. Goldblatt laboratory (Mount Sinai Hospital, Cleveland) 1956 Invited to head Pharmacology Department at Université de Montreal (1967) See Brazilian Journal of Medical and Biological Research 20(5):485-6, 1987