Antonio Sidney Pompeu
Antonio Sidney Pompeu, Brazilian plant geneticist (Taquaritinga, São Paulo State 16 June 1938 – Of Italian descent from paternal side DEVELOPED NEW VARIETIES OF DRY-BEANS With O. Paradela Filho. Novas linhagens do feijoeiro (Phaseolus vulgaris) dos grupos Rosinha e Roxinho, resistentes ao fungo da antracnose (Colletotrichum lindemuthianum). Summa Phytopath. 5(3-4):153-8, 1979 Catú, Aeté 3, Aroana 80, Moruna 80, Carioca 80 & Aysó (1982) IAC-Oirã, IAC-Poitara & IAC-Tupã (1987) IAC-Maravilha, IAC-Una, IAC-Carioca Pyatã, IAC Carioca Aruã, IAC Carioca Akytã & IAC-Bico de Ouro (1997) IAC- Carioca Eté & IAC-Carioca Tybatã (1999) with S.A.M. Carbonell, M.F. Ito & N. Bortoletto IAC-Votuporanga, IAC-Ybaté & IAC-Apuã (2005) PLANT PATHOLOGY With L.V. Crowder. Methods of inoculation and bacterial concentrations of Xanthomonas phaseoli Dows for the inheritance of disease reaction in Phaseolus vulgaris crosses (dry-beans), under growth conditions. Cien. Cult. 25(11):1078-81, 1973 With O. Paradela Filho & M.F. Ito. Novas raças fisiológicas de Colletotrichum lindemuthianum (Sacc. & Magn.) Scrib. (1982)
Antonio Maria Pineda
Antonio María Pineda Bujanda, Venezuelan surgeon (Barquisimeto, Lara State 27 September 1850 – Barquisimeto, Lara State 05 October 1941) Authored over 50 medical works INVENTIONS Folding operation tables Pineda catheter An electric thermometer (Pineda ideal thermometer) An eye teno-neurotome used to section of optical nerve (presented in 1922) Spatula for removal of foreign bodies in bladder A spatula for dissections A cautery torch Pineda probe for urinary retention A procedure to make refractory clay made instruments (1917) Magic tube for poising railways
Antonio Carlos Pacheco e Silva
Antonio Carlos Pacheco e Silva, Brazilian neuropsychiatrist (São Paulo 29 May 1898 – São Paulo 27 May 1988) Authored original studies about general pathology of syphilitic infection of the nervous centers with many citations in literature Related the presence of Schaudinn spirochaeta in the tissues of nervous centers within the lymphatic channels (Virchow-Robin spaces) and in the proximity of the blood vessels, as well as in the intimate fibers of optic vessels Demonstrated the granular form of syphilis germ in brain With C. Tretiakoff. Uma forma particular da síndrome peduncular alterna. Mem. Hosp. Juqueri 1:101-6, 1924 Eponym of Pacheco e Silva-Oliveira Bastos blepharospasm sign in Parkinson disease OFFICES President, World Federation for Mental Health (1960-1)
Antonio & Therezinha Paiva
Antonio Cechelli de Mattos Paiva, Brazilian biochemist (Mogi Mirim, São Paulo State 21 June 1929 – São Paulo 18 May 2006) Authored about 150 papers With his wife gained international recognition for their work on polypeptides syntheses SYNTHESES OF PEPTIDES With T.B. Paiva et al. New specific antagonists of angiotensin I and II (1973) With T.B. Paiva & M.E. Miyamoto. An analogue peptide of pepsitensin (1973) With T.B. Paiva & M.E. Miyamoto. Synthesis of a proposed pepsitensin. J. Med. Chem. 16(3):280, 1973 With M. Tominaga, J.M. Stewart & T.B. Paiva. New bradykinin potentiating peptides (1975) With G. Goissis & V.L.A. Nouailhetas. Biologically active retroenantiomers of angiotensin peptides (1976) With C.R. Nakaie, M.E.M. Oshiro & G. Goissis. New peptide analogues of angiotensin II (1977) With E.B. Sabia, M. Tominaga & T.B. Paiva. New analogues of snake venom peptides (1978) With C.R. Nakaie, E.G. Silva, E.M. Cilli, R. Marchetto, S. Schreier & T.B. Paiva. Synthesis and pharmacological properties of TOAC-labeled angiotensin and bradykinin analogs. Peptides 23(1):65-70, 2002 OTHER CONTRIBUTIONS With T.B. Paiva & J.L. Prado demonstrated that angiotensin and pepsitensin were distinct substances Non-identity between pepsitensin and hypertension revealed by paper electrophoresis. Science 120:611, 1954 With T.B. Paiva. The importance of the N-terminal of angiotensin II for its pressor and oxytocic activities. Biochem. Pharmacol. 5:181, 1960 With V.L.A. Nouailhetas, M.E. Miyamoto, G.B. Mendes & T.B. Paiva. New specific angiotensin inhibitors. J. Med. Chem. 16(1):6-9, 1973 With L. Oliveira & G. Vriend. A common step for signal transduction in G protein-coupled receptors. J. Comput. Aided Mol. Des. 7:649-58, 1993 A novel enzyme with activity tonin-like from rat submandibular gland (1993) With N.L. Miasiro. Specific endothelin receptor agonists and antagonists disclose two new Etb receptors in the guinea pig ileum. Abst. XII Intern. Congr. Pharmacology p.572, 1994 With L. Oliveira & G. Vriend. A low resolution model for the interaction of G proteins with G-protein coupled receptors. Protein Engin. 12:1087-95, 1999 With M. Tominaga, S.R. Barbosa, S. Schreier, C.R. Nakaie et al. Fmoc-POAC: [(9-fluorenylmethyloxycarbonyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl-3-amino-4-carboxylic acid]: A novel protected spin labeled amino acid for peptide and protein chemistry. Chem. Pharm. Bulletin 49(8):1027-9, 2001 With L. Oliveira, P.B. Paiva & G. Vriend. Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein. Proteins 52:553-60, 2003 BRAZILIAN PATENTS With C.R. Nakaie, M. Tominaga, S.R. Barbosa, R. Marchetto & S. Schreier. Síntese de um novo derivado de aminoacido paramagnético (epm-5) para uso em marcação de diferentes macromoléculas e sistemas de interesse químico-biológico PI9903137-0 A2 (1999) With J.B. Pesquero, J.L. Pesquero, R.C. Araújo, M.A.S. Mori & M.S. Bader. Mecanismos e drogas utilizados no tratamento de diabetes, obesidade e controle dos distúrbios da fome (2005) HONOURS 100 Best Scientists of the World, Banning Foundation, Cambridge, United Kingdom (2006) His wife, Therezinha Bandiera de Paiva, pharmacologist (Paraguaçu Paulista, São Paulo State 20 April 1929 – São Paulo 15 March 2011) From Italian descent See above BRAZILIAN PATENT With E. Achar, A.H. Campos, W.S. Almeida, R.A.N. Achar & N. Schor. Uso da amitriptilina, composição, forma farmacêutica, produto alimentício e método para prevenção, tratamento e eliminação de cálculos renais em animais PI0400994-0 A2 (2004) With E. Achar, A.H. Campos, W.S. Almeida, R.A.N. Achar & N. Schor. Uso da amitriptilina, composição, forma farmaceutica, produto alimentício e método para prevenção, tratamento e eliminação de cálculos renais em humanos PI0400995-9 A2 (2004)
Anita Dolly Panek
Anita Dolly Haubenstock Panek, Polish-born Jewish Brazilian biochemist (Cracow 01 September 1930 – Rio de Janeiro 27 March 2024) Authored about 160 papers Determined the primary function of trehalose in baker’s yeast as an energy source for cell division Function of trehalose in yeast cells. Arch. Biochim. Biophys. 98:349, 1962 Showed that endogenous trehalose protects cells against damage caused by freezing (1988) Demonstrated that the trehalose is required for survival of cells when submitted to various kinds of stresses such as dehydration, ethanol, heat and germination Purified partially baker’s yeast trehalase With N.O. Souza. Purification and properties of baker’s yeast trehalase. J. Biol. Chem. 239(6):1671-3, 1964 Showed the existence of a trehalose transport mechanism in yeasts With P.S. Araujo, A.C. Panek, J.H. Crowe & L.M. Crowe. Trehalose-transporting membrane vesicles from yeasts. Biochem. Int. 24(4):731-7, 1991 Papers with over 100 citations With E. Eleutherio, J.F.Mesquita, E. Trevisol & R.S.S. Magalhães. Revisiting yeast trehalose metabolism. Curr. Genet. 61:263-74, 2015 With F.A.V. Castro, D. Mariano, E.C.A. Eleutherio & M.D. Pereira. Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae. PLoS One 3:e3999, 2008 With M.B. França & E.C.A. Eleutherio. Oxidative stress and its effects during dehydration. Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 146(4):621-31, 2007 With R.S. Herdeiro, M.D. Pereira & E. Eleutherio. Trehalose protects Saccharomyces cerevisiae from lipid peroxidation during oxidative stress. Biochim. Biophys. Acta 1760(3):340-6, 2006 With C.G. Silva, R.S. Herdeiro, C.J. Mathias, C.S. Silveira, V.P. Rodrigues et al. Evaluation of antioxidant activity of Brazilian plants. Pharmacol. Res. 52(3):229-33, 2005 With P.D.B. Adams, D.S. Gomes, M.L.C. Pinto & E. Eleutherio. The role of glutathione transferases in cadmium stress. Toxicol. Lett. 154(1-2):81-8, 2004 With E.J. Pereira & E. Eleutherio. Protection against oxidation during dehydration of yeast. Cell Stress & Chaperon. 8(2):120-4, 2003 With D.S. Gomes, L.C. Fragoso, C. Riger & E. Eleutherio. Regulation of cadmium uptake by Saccharomyces cerevisiae. Biochim. Biophys. Acta 1573(1):231-5, 2002 With M.D. Pereira & E. Eleutherio. Acquisition of tolerance against oxidative damage in Saccharomyces cerevisiae. BMC Microbiol. 1(11), 2001 With L. Diniz Mendes, E. Bernardes, P.D. Araújo & V. Paschoalin. Preservation of frozen yeast cells by trehalose. Biotechnol. Bio. 65(5):572-8, 1999 With J. Mansure, L. Crowe & J. Crowe. Trehalose inhibits ethanol effects on intact yeast cells and liposomes. Biochim. Biophys. Acta 1191(2):309-16, 1994 With E.C.A. Eleutherio & P.D. Araújo. Role of the trehalose carrier in dehydration resistance of Saccharomyces cerevisiae. Biochim. Biophys. Acta 1156(3):263-6, 1993 With E. Eleutherio & P.D. Araújo. Protective role of trehalose during heat stress in Sacharomyces cerevisiae. Cryobiology 30(6):591-6, 1993 With C. Coutinho, E. Bernardes & D. Felix. Trehalose as cryoprotectant for preservation of yeast strains. J. Biotechnol. 7(1):23-32, 1988 With A.B. Valle & J. Mattoon. Colorimetric determination of succinic acid using yeast succinate dehydrogenase. Anal. Biochim. 91(2):583-99, 1978 METHODS, TECHNIQUES AND PROCESSES With A.S. Martins, D.N. Peixoto, L.M.C. Paiva & C.L. A. Paiva. A simple method for obtaining reusable reactors containing immobilized trehalase: Characterization of a crude trehalase preparation immobilized on chitin particles. Enzyme and Microbial Technology 38:486-492, 2006. With B.U. Stambuk, J.H. Crowe, L.M. Crowe & P.S. Araújo. A Dependable Method For The Synthesis Of [C14] Trehalose. Anal. Biochem. 212:150-153, 1993. With R.M. Ferreira, M.B. Dutra, V.M.F. Paschoalin & J.T. Silva. A new method for the purification of yeast Hsp26p (1999) With R.M.A. Soler et al. A simple enzymatic method for trehalose quantification (1996) With P.S. Araújo, A.C. Panek & R.Ferreira. Determination of trehalose in biological samples by a simple and stable trehalase preparation. Anal. Biochem. 176(2):432-6, 1989 With A.B. Valle & J.R. Mattoon. Colorimetric determination of succinic acid using yeast succinate dehydrogenase. Anal. Biochem. 91(2):583-99, 1978 PATENTS With E.C.A. Eleutherio patented a process for protecting and maintenance of human, animal and plant tissues employing trehalose PI9400068-9 (1994) With C. Meleiro & V.M.F. Paschoalin developed a process for obtaining trehalose from Saccharomyces cerevisiae PI9303490-3 (1993) With N. Bachinski, V.M.F. Paschoalin & C.L.A. Paiva developed a process to obtaining, purification and immobilization of trehalase from Escherichia coli. Process employing soluble and/or immobilized trehalase in enzymatic dosage of trehalose (1993)
Angelo Pires do Prado
Angelo Pires do Prado, Brazilian entomologist (São Lourenço do Sul, Rio Grande do Sul State 01 February 1942 – Campinas, São Paulo State 25 August 2013) Authored one book and 117 papers DESCRIBED DIPTERA TAXA Family Syringogastridae 1969 Genera Aristocerina 1975 with Borgmeier Brachyphlebina 1975 with Borgmeier Brachycosta 1976 Borgmeieria 1976 Borgmeiriphora 1976 Colyeria 1975 with Borgmeier Cyrtophorina 1975 with Borgmeier Dorsochaeta 1975 with Borgmeier Lenkokroeberia 1966 Lopesiodinia 1973 Neotraginops 1973 Paraphryssopoda 1983 with Guimarães & Papavero Platydipteron 1975 with Borgmeier Stylusa 1975 with Borgmeier Trichocerina 1975 with Borgmeier Species About 100 HONORS Pradomyia Gaimard 2007 (Diptera)