Enrique Hong Chong, Mexican pharmacologist (Tampico, Tamaulipas State 11 June 1938 –

From Chinese ancestry

Contributions

Stimulation of central serotonin receptors as a novel mechanism of antihypertensive activity (1983)

With P. Nava Felix. Nature of the central serotonin receptors mediating hypotension. J. Cardiovasc. Pharmacol. 1(4):461-6, 1979

Described and characterized new drugs

Described zolertine, an antihypertensive agent with a special profile of an adrenergic blocking action (1965)

With R. Rodríguez, H. Vidrio & E.G. Pardo. Pharmacology of a group of phenylpiperazine tetrazole derivatives with adrenergic blocking actions. J. Pharmacol. Exper. Therapy 148(1):54-65, 1965

With H. Vidrio, R. Rodríguez, J.L. Magaña, R. Vargas & R.G. Pardo. General pharmacology of zolertine, a new antihypertensive agent. Gac. Med. Mexico 98(9):1218-41, 1968

Described quipazine, the first synthetic serotonin agonist that was able to be absorbed from the oral route and to penetrate the blood brain barrier

With L.F. Sancilio, R. Vargas & E.G. Pardo. Similarities between the pharmacological actions of quipazine and serotonin. Europ. J. Pharmacol. 6(3):274-80, 1969

with R. Rion & H. Vidrio, described Indorenate (TR3369), an agonist of 5-HT1A receptors with central antihypertensive properties

With P. Nava Felix & H. Vidrio. Central antihypertensive effect of a new tryptamine derivative. Pharmacologist 20(3):188, 1978

Described rioprostil, a prostaglandin-like drug

With D.A. Shriver, M.E. Rosenthale, H.C. Kluender, R.N. Schut & J.L. McGuire. Pharmacology of rioprostil, a new gastric cytoprotective/antisecretory agent. Drug Research 35(5):839-43, 1985

Described pelanserin

With F.J. Flores Murrieta & G. Castañeda Hernandez. Sensitive high-performance liquid chromatographic assay of pelanserin, a novel antihypertensive agent, in plasma samples. J. Chromat. B. Biomed. Sci. Appl. 428:167-72, 1988

With H. Vidrio & M.A. Mena. Antiarrhythmic activity of TR2985, a novel diphenylhydantoin derivative (1980)

With G. Reyes & T. Ramírez. Distinct cardioselectivity of TR2732, a new beta adrenergic blocking agent. Proceed. West Pharmacol. Soc. 34:141-4, 1991

With J.A. Terrón, F.J. López Muñoz & C.M. Villalon. 2-(2-aminoethyl)-quinoline (D-1997): a novel agonist at 5-hydroxytryptamine 1-like receptors in the canine basilar artery. Arch. Intern. Pharmacodyn. Therapie 327(1):56-68, 1994

OTHER CONTRIBUTIONS (methods and models)

Indorenate, an useful tool to detect several 5-HT-related pharmacological activities. Acta Pharmacol. Sinica 27(9):1273, 2006

With R. Rodríguez, I. Rodríguez Boscan, D. Lugo Sira, H. Vidrio, M. Medina & I. Herrera. Bilateral sequential common carotid artery sectioning in mice as a new model for testing neuroprotective drugs. J. Stroke Cerebrovasc. Dis. 9(1):45-53, 2000

With F.J. Flores-Murrieta & V. Granados Soto. Determination of ketorolac in blood and plasma samples by high-performance liquid chromatography. Bol. Chim. Farmac. 133(9):588-91, 1994

With F.J. Flores-Murrieta & V. Granados Soto. A simple and rapid method for determination of fluconazole in human plasma samples by high-performance liquid chromatography. J. Liqu. Chromat. Relat. Technology 17(17):3803-11, 1994

With A. Meneses. Spontaneously hypertensive rats: a potential model to identify drugs for treatment of learning disorders. Hypertension 31(4):968-72, 1998

PATENTS

Foreign

With R.N. Schut & M.E. Safdy. Methyl-3-acetamido-2(5-methoxy-indol-3-yl) propanoate and hypotensive use thereof. US Pat. 4,393,081 (1983) EP0078431A1 (1983)

With R.N. Schut & M.E. Safdy. Process for the preparation of 3-amino-2(5-fluoro-and 5-methoxy-1H-indol-3-yl) propanoic acid derivatives. US Pat. 4,283,336A (1981)

With R.N. Schut & M.E. Safdy. 3-amino-or-amido-2(1H-indol-3-yl) propanoic acid derivatives. US Pat. 4,283,410 (1981)

With M.E. Safdy & R.N. Schut. 3-amino-2 (5-fluoro and 5-methoxy-1h-indol-3-yl) propanoic acid derivatives CA1098910A (1981)

Method of antihypertensive chemotherapy utilizing 1-methyl-3-keto-phenylquinuclidium salts. US Pat. 3,860,717 (1975)

Mexican

With J.M.L. Medina Contreras. Metodos para incrementar la sensibilidad a la insulina mediante agonistas de receptores serotonérgicos 5Ht2 MX363662B (2019)

With V.I. Granados Soto & I. Araiza Saldaña. Metodo para evitar o retrasar la aparición de alodinea por medio del tratamiento con inhibidores de la enzima convertedora de angiotensina MX/360184B (2018)

With F.Y. Huang & O. Echeverría Rodríguez. Losartan effect over perivascular adipose tissue and metabolic syndrome treatment. MX2010010371 A (2010)

With G. Aguirre Hernandez, F. Ramírez Romero, I.A. Rivero Espejel & R.S. Ramaswamy. Procedure for the synthesis of monohydrated dichlorhidrated of 3-(3(4-fenil-1-piperacil) propil-)2,4 (1H,3H)-quinazolinedione (pelanserine) and resulting product. MX9206713A (1992)