Gastão Rosenfeld, Hungarian-born Jewish Brazilian biomedical scientist (Budapest 26 July 1912 – São Paulo 15 July 1990)

From Hungarian father and Egyptian mother from French ascent

ACHIEVEMENTS

Studied properties of natural toxins

Authored many important studies on physiopathology of poisoning by animals 

A new method for studying Hematozoa

Novo método para pesquisa de hematozoários. Rev. Assoc. Paul. Med. 18:306, 1941

Método rápido de coloração de esfregaços de sangue. Noções práticas sobre corantes pancrômico e estudo de diversos fatores. Mem. Inst. Butantan 20:315-28, 1947

Developed Rosenfeld staining, a rapid pan-chromic staining for blood smears combining May-Grunwald and Giemsa methods 

Corante pancrômico para a hematologia e citologia clínica: nova combinação dos componentes do May-Grunwald e do Giemnsa num só corante de emprego rápido. Mem. Inst. Butantan 20:329-334, 1947

Co-discovered bradykinin (1949)

With M. Rocha e Silva & W.T. Beraldo. Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin. Am. J. Physiol. 156:261-73, 1949

With L.A.P. de Camargo. Retração normal do coágulo sanguíneo. Coeficiente de correção e índice de retração. Rev. Bras. Biol. 9:510, 1949

With B. Janszky & A.T. Leão. Método de investigação da ação de drogas sobre a coagulabilidade do sangue “in vivo”. Seara Med. 6:515, 1951

Introduced a new treatment for chronic leukemia using personal control of maintenance dosis

Considerations on the classification frequence and treatment of leukemia. Acta Unio Int. Contra Cancrum 11(3):313-7, 1955

With O.G. Hampe & E.M. Kélen. Coagulant and fibrinolytic activity of animal venoms: determination of coagulant and fibrinolytic index of different species. Mem. Inst. Butantan 29:143-63, 1959 

With E.M.A. Kelen & F. Nudel. Hemolytic activity of animal venoms. I. Classification in different types and activities. Mem. Inst. Butantan 30, 1960

Described in detail Rosenfeld neurotoxic facies or myasthenic facies, a pathognomonic sign of the bite by a snake with neurotoxic venom (1960s)   

Developed a modified standard technique for determining coagulation time

Técnica padrão da determinação do tempo de coagulação (modificado). J. Bras. Med. 7:695-711, 1965  

With W. Beçak & M.A.R. Barros. Método fotométrico para medição quantitativa de cromossomos (1965)

Described hementerin, an anticoagulant of leech Haementeria lutzi

With Eva M. A. Kélen. Fibrinogenolytic substance (hementerin) of Brazilian blood-sucking leeches (Haementeria lutzi Pinto 1920). Haemostasis 4(1): 51-64, 1975

Paper in Science

With B. Janszky. The accelerating effect of calcium on the fibrinogen-fibrin transformation. Science 116:36-7, 1952