Biography
José Mordoh, Argentine molecular biologist and oncologist (Buenos Aires 19 February 1939 –
Authored 140 papers
Demonstrated the fundamental role of cellular membrane in transduction of mitogenic signs to nucleus
Demonstrated the presence of stem cells in breast cancer
Established melanoma and breast cancer human cells lines for studies in vitro and in vivo such as IIB-BR-G (1991), IIB-MEL-J (1989), IIB-MEL-LES & IIB-MEL-IAN (1995)
With Susan Blau. A new element in the control of DNA initiation in Escherichia coli. Proc. Natl. Acad. Sci. USA 69(10):2895-8, 1972
With A.O. Pogo & J.R. Cordero Funes. Cytophotometry of DNA in liver cell nuclei duiring postnatal growith. New aspects of DNA class cells. Exp. Cell Res. 21:482-97, 1960
With B.R. Friedlander. Synthesis of a compound soluble in organic solvents from deoxycytidine triphosphate in permeabilized normal human lymphocytes. Mol. Cell. Biochem. 16(2):177-85, 1977
With S. Leis, A.I. Bravo, O.L. Podhajcer, C. Ballaré, M. Capurro, C. Kairiyama & L. Bover. Description of a new monoclonal antibody, FC-2.15, reactive with human breast cancer and other human neoplasias. Int. J. Biol. Markers 9(3):125-34, 1994
With I.J. Tapia, M. Aris, J.M. Arriaga, P.A. Blanco et al. Development of a novel methodology for cryopreservation of melanoma cells applied to CSF470 therapeutic vaccine. Cryobiology 67(2):163-9, 2013
First to demonstrate that after irradiation a fraction of tumor cells present large lipid bodies which mainly contain high concentration of triglycerides
With G.A. Pizzurro, F.P. Madorsky Rowdo, I.M. Pujol-Lereis, A.M. Copati, M.P. Roberti, J.L, Teillaud, E.M. Levy, M.M. Barrio & L Quesada Allué. High lipid content of irradiated human melanoma cells does not affect cytokine-maturated dendritic cell function. Cancer Immunol. Immunother. 62(1):3-15, 2013
Papers in top journals
With M. Resnicoff, E.E. Medrano, O.L. Podhajcer, A.I. Bravo & L. Bover. Subpopulations of MCF7 cells separated by Percoll gradient centrifugation: a model to analyze the heterogeneity of human breast cancer. Proc. Natl. Acad. Sci. USA 84(20):7295-9, 1987
With S. Cabral, S. Leis, L. Bover & M. Nembrot. Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells. Proc. Natl. Acad. Sci. USA 81(10):3200-3, 1984
With B.R. Friedlander & E.E. Medrano. Synthesis of DNA in human lymphocytes: possible control mechanism. Proc. Natl. Acad. Sci. USA 71(4):1128-32, 1974
With Y. Hirota & F. Jacob. On the process of cellular division in Escherichia coli. V. Incorporation of deoxynucleoside triphosphates by DNA thermosensitive mutants of Escherichia coli also lacking DNA polymerase activity. Proc. Natl. Acad. Sci. USA 67(2):773-8, 1970
With L.F. Leloir & C.R. Krisman. In vitro synthesis of particulate glycogen. Proc. Natl. Acad. Sci. USA 53:86-91, 1965
PATENTS
With O.L. Podhajcer, S.L. de Cerone & A.I. Bravo. Monoclonal antibodies reactive with tumour proliferating cells. US Patent 5753229 A (1991)
With M.M. Barrio & E.M. Von Euw. Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. ARP070101502A (2007) EP08737810A (2008) PCT/IB2008/051385 (2008) CO6260100A2 (2009) WO 2008126039 patents in Australia, Canadá, Denmark, New Zealand, United States, Japan, Korea, Spain, Mexico, Russia, China & South Africa
With G.A. Rabinovich, O.L. Podhajcer, L. Fainboim, M. Alvarez & N. Rubinstein. A composition, a vector and a method used in anti-tumoral therapy, and use of galectin-1 (gal-1) inhibitors in the preparation of a medicinal product for tumor cell therapy AR037550A1 (2002)
With O.L. Podhajcer, M.F. Ledda, S.A. Adris, A.I. Bravo & Y. Chernajovsky. Compositions and methods for tumour therapy. EP090097A2 (1997) PCT/GB1997/003548 (1997) WO1998/029138 & EP0950097 (1999) patents in Australia and United States