Biography
Carlos Larralde Rangel, Mexican immunopathologist (Monterrey, Nuevo León State 11 April 1938 – Ciudad de Mexico 04 January 2015)
CONTRIBUTIONS
Showed that immune cells communicate and regulate each other in every immunological event
In vitro mitotic activity of unsensitized lymphocytes in the presence of antigens and sensitized lymphocytes. Proc. Soc. Exp. Biol. Med. 133:1175-7, 1970
Showed the role of antigen valence in the probability of binding to its antibody and the quantitative description of the actual distribution of affinities in an antibody population
With M.V. José. Alternative interpretation of unusual Scatchard plots: contribution of interactions and heterogeneity. Mathem. Biosciences 58(2):159-70, 1982
With G. Fragoso & E. Sciutto developed S3Pvac vaccine against porcine and murine cysticercosis
With M. Viveros, C. Dickey, J.P. Cotropia, G. Gevorkian, K. Broliden et al. Characterization of a novel human immunodeficiency virus type 1 neutralizable epitope within the immunodominant region of gp41. Virology 270(1):135-45, 2000
First report of the detection and functionality of AP-1 transcription factor genes in any species of helminth parasites
With J. Morales-Montor, G. Escobedo, M. Rodríguez-Dorantes, N. Tellez-Ascencio & M. Cerbón. Differential expression of AP-1 transcription factor gene c-fos and c-jun in the helminth parasites Taenia crassiceps and Taenia solium. Parasitology 129 (2), 2004
With J. Morales-Montor, G. Escobedo & J.A. Vargas-Villavicencio. The neuroimmunoendocrine network in the complex host-parasite relationship during murine cysticercosis. Curr. Top. Med. Chem. 8(5):400-7, 2008
METHODS
With A. Flisser & J.P. Laclette developed serum and stool tests for taeniasis using polyclonal antibodies
With L. Huerta, E. Lannoyi & A. Baez Saldaña. Human immunodeficiency virus envelope-dependent cell-cell fusion: a quantitative fluorescence cytometric assay. Cytometry 47(2):100-6, 2002
With G.G. Gevorkian, M. Viveros & F. Zamudio. Solid-phase synthesis of a peptide comprising the 605-611 disulfide loop of gp41, transmembrane glycoprotein of human immunodeficiency virus type I (HIV-I). Oppi Briefs 27(3):375-7, 1995
With G. Fragoso, F. Valdez, Y. Rosenstein, T. Govezenensky & E. Sciutto. Immunoenzymatic assay that measures the expression of murine histocompatibility antigens in macrophages and lymphocytes. J. Clin. Lab. Analysis 7(6):348-52, 1993
With E. Sciutto, B. Garat & E. Ortega. Antibody heterogeneity: theoretical and experimental evaluation of a simple procedure to describe differing affinities in hapten binding reactions. Mol. Immunol. 24(6):577-85, 1987
MEXICAN PATENTS
With G.C. Fragoso Gonzalez, M. Hernandez Gonzalez, A. Schuneman de Aluja, N. Martínez Villalobos, J.E, Sotelo Morales, E.L. Sciutto Conde, K. Manoutchian Airapetiani, G. Gevorkian Markosian, E. García Mendoza & M.A. Huerta Orea. Tres péptidos sinteticos para utilizarse en la vacunación y diagnostico de cisticercose por Taenia solium MX1998005424, MX2002007436, MX2002007437 & MX2002007438
With J.P. Laclette, R.M. Montoya, T. Govezenensky, M.L. Díaz Servín & F. Goodsaid Zalduondo. Procedimiento para la obtención de los antigenos del fluido vesicular del cisticerco de la Taenia solium P.170506 (1993)
HONORS
Larraldiella Brailovsky 1999 (Hemiptera)
