Dulal Pada Sadhu
Dulal Pada Sadhu, Indian nutritional physiologist (Kapilmuni, Bangladesh 09 May 1916 – ?) ACHIEVEMENTS Discovered the role of deamination and transamination on the protein action mechanism in rats and ruminants Discovered the fundamental mechanism in the field of energy exchange in the living organism Demonstrated the stenothermal stage in the evolution of thermal regulation in animals SOME BIBLIOGRAPHY Effect of feeding higher doses of urea on the rumen metabolism in goat. Ind. Vet. J. 45:735-9, 1986 With S.N. Das. Effect of acetazolamide on insulin sensitivity in dogs with alloxan diabetes. Ind. J. Physiol. Pharmacol. 22:301-4, 1978 With S.K. Basu. Skin thermometry of rats under different ambient temperatures. Ind. J. exp. Biol. 15(12), 1977 With S.S. Tripathi & M.V.N. Rao. Effect of thermal stress on certain blood constituents in hill steers. Ind. J. Anim. Health 17:47, 1976 With B. Singh & B.B. Mahapatro. Chemical composition of cattle and buffalo spermatozoa and seminal plasma under different climatic conditions (1969) With D.R. Chowdhry. Consumption of oxygen by sweat glands of Indian zebu cattle. Nature 198:311, 196? With D.R. Chowdhry. Rate of evaporation from different regions of the skin of Indian zebu cattle. Nature 189:491, 1961 With S. Chaudhuri. Thyroid activity at higher ambient temperatures. Nature 192:560-1, 1961 With S. Chaudhuri. The role of the adrenergic system in the thermoglycemic response in baby rabbits. Am. J. Physiol. 199:727-8, 1960 With A. Goswami. Polyenoic acid in hypercholesterolemia induced by pyridoxine deficiency in rats. Nature 187:786, 1960 With K.P. Chakravorti. Some aspects of the histochemical studies on the oviduct of the pigeon, Columba livia Gmelin. Proc. Zool. Soc. Calcutta 12:9-14, 1959 With N.K. Das. Haematological studies in Indian goats. Proc. 42nd Ind. Sci. Congress 3:347, 1955 With S. Mookerjea. Metabolic depression by arsenite and malonate and cholesterologenesis. Arch. Biochem. Biophys. 58:232-6, 1955 With S.N. Ray. Histamine and carbohydrate metabolism (1955) Influence of lactose on the transglycosidation of sphingosine base in the rat brain. Am. J. Physiol. 175:283-4, 1953 Role of fat on utilization of lactose in milk by rats and rabbits. Proc. Soc. Exp. Biol. Med. 77:585, 1952 With B.L. Truscott. Effect of hypervitaminosis A and of reticuloendothelial system blockade on the thyroid. Anat. Rec. 100:719, 1948 With B.L. Truscott. Hypervitaminosis A and distribution of body iodine. Endocr. 43:120-8, 1948 Vitamin A, iodide and thyrotropic hormone content on the anterior pituitary. Am. J. Physiol. 152:263, 1948 Physiological mechanism of experimental goitrogenesis. Am.J. Physiol. 152:150, 1948 With S. Brody. Thiouracil, basal metabolism and specific dynamic action. Am. J. physiol. 151:130-3, 1947 With S. Brody. Excess vitamin A ingestion, thyroid size and energy metabolism. Am, J. Physiol. 149:400-3, 1947 With S. Brody. The nutritional significance of milk with special reference to milk sugar. Scient. Month. 64(1):5-13, 1947 Growth and development with special reference to domestic animals. The specific dynamic action of nutrients with special reference to the effects of vitamins and hormones (1947)
Diogenes Santiago Santos
Diógenes Santiago Santos, Brazilian microbiologist, biochemist and molecular biologist (Gandu, Bahia State 28 June 1942 – Porto Alegre 23 June 2017) Authored about 200 scientific works (with about 3,000 citations and h index 31) Solved the three-dimensional structure of 39 proteins deposited in Protein Data Bank (PDB) With I. Schrank, A. Zaha & E.F. Araújo. Construction of a gene library from Azospirillum brasilense and characterization of a recombinant containing the nif structural genes. Braz. J. Med. Biol. Research 20:321-30, 1988 With J.C.D. Hinton, A. Sarafi, J. Sidebotham, C. Higgins, T.A. Owenhughes & G.D. Pavitt. H-NS A Novel DNA-Binding Protein Involved in Maintaining Chromatin Structure and Regulating gene Expression. Journal of Cellular Biochemistry 8(Suppl.), 295-6, 1993 With J. Rakonjac, M. Milic, R. Ivanisevic & D. Savic. Nov a New Genetic Locus that Affects Response of Escherichia coli to Novobiocin. Molecular Microbiology, 6(11):1547-53, 1992 With A. H. R. Paz, S. Rief, E. Wolf, K. Prelle & E.O.C. Lima. Mouse embryonic stem cells: The establishment of the system to produce differentiated cell types in vitro. Acta Scientiae Veterinariae 31(1):51-4, 2003 With J.S. de Oliveira, L.A. Basso, M. Palaci, R. Dietze & I.S. Moreira. An inorganic iron complex that inhibits wild type and an isoniazid-resistant mutant 2 trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. Chemical Communications 3:312-3, 2004 With F. Canduri, V. Fadel, L. A. Basso, M.S. Palma & W.F. Azevedo Jr. New catalytic mechanism for human Purine nucleoside Phosphorilase. Biochemical and Biophysical Research Communications 327:646-9, 2005 With E.H. de Souza, D.L. Pontes, I.C. N. Diogenes, E. Longhinotti, L.G.F. Lopes, J.S. de Oliveira, L.A. Basso & I.S. Moreira. Electron Transfer Kinetics and Mechanism Study of the Thionicotinamide Coordinate to the Ironpentacyano (II) and (III) Complexes: A Model System for the in vitro Activation of Thioamides anti-tuberculosis drugs. Journal of Inorganic Biochemistry 99:368-75, 2005 With B.A.D Neto, F.S Mancilha, I.B. Vasconcelos, C. Thum, L.A. Basso & J. Dupont New Sensitive Fluorophores for Selective DNA detection. Organic Letters 9:4001-4, 2007 With C.L. Fernandes, A. Breda, L.A. Basso & O.N. de Souza. A Structural Model for Chorismate Synthase from Mycobacterium tuberculosis in Complex with Coenzyme and Substrate. Computers in Biology and Medicine 37:149-58, 2007 With I.C. Werlang, C. Schneider & L.A. Basso. Identification of Rv3852 as a nucleoid-associated protein in Mycobacterium tuberculosis. Microbiology 155:2652-63, 2009 With L.A. Basso, C.Z. Schneider, A. J. A. B. Santos & M.M. Campos. An inorganic Complex that Inhibits Mycobacterium tuberculosis Enoyl Reductase as a Prototype of a New Class of Chemotherapeutic Agents to Treat Tuberculosis. Journal of the Brazilian Chemical Society 7:1384-89, 2010 With E.H. de Souza, L.A. Basso, I.C.N. Diogenes, E. Longhinotti, L.G. F. Lopes & I. S. Moreira. Isoniazid metal complex reactivity and insights for a novel anti-tubercular drug. JBIC. Journal of Biological Inorganic Chemistry 17:275-83, 2012 With M.C de Moraes, R. G. Ducati, A.J. Donato, L.A. Basso, C.L. Cardoso & Q.B. Cass. Capillary bioractors based on human Purine Nucleoside Phosphorylase: a new approach for ligands indetification and characterization. Journal of Chromatography 1232:110-5, 2012 With I. Pauli, R.N. dos Santos, D.C. Rostirolla, L.K. Martinelli, R.G. Ducati, L.F.S. Timmers, L.A. Basso, R.V.C. Guido, A.D. Andricopulo & O.N. Souza. Discovery of New Inhibitors of Mycobacterium tuberculosis InhA Enzyme Using Virtual Screening and a 3D-Pharmacophore-Based Approach. Journal of Chemical Information and Modeling 53:2390-2401, 2013 With D. Renck, P. Machado, A.A. Souto, L.A. Rosado, T. Erig, M.M. Campos, C.B. Farias, R. Roesler, Luis F.S. Timmers, O.N. de Souza & L.A. Basso. Design of Novel Potent Inhibitors of Human Uridine Phosphorylase-1: Synthesis, Inhibition Studies, Thermodynamics, and in Vitro Influence on 5-Fluorouracil Cytotoxicity. Journal of Medicinal Chemistry 56:8892-02, 2013 With P. Machado, E. Ritter, A.J.B. dos Santos, C. Neves & L.A. Basso. Ultrasound-assisted improvement of drug solubility: a simple and useful method for the formation of salts from 4-hydroxy-6-methyl-3-nitropyridin-2(1H)-one. Monatshefte fur Chemie , 144:1165-70, 2013 With D. Renck, A. Santos Jr., P. Machado, G.O. Petersen, T. J. Lopes, M.M. Campos, & L.A. Basso. Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil induced intestinal mucosositis. Investigational New Drugs (2014) With G.O. Petersen, S. Saxena, J. Renuka, V. Soni, P. Yogeeswari, C.V. Bizarro & D. Sriram. Structure-based virtual screening as a tool for the identification of novel inhibitors against Mycobacterium tuberculosis 3-dehydroquinate dehydratase. Journal of Molecular Graphics & Modelling , (2015) With G. Cattaneo, D. Ubiali, E. Calleri, M. Rabuffetti, G.C. Höfner, K.T. wanner, M.C. de Moraes, L.K.B. Martinelli, G. Speranza & G. Massolini. Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase. Analytica Chimica Acta 943: 89-97, 2016 With T. Gazzi, M. Rotta, A. Villela, V. Rodrigues Jr., L. Martinelli, F. Sales, E. de Sousa, M. Campos, L.A. Basso & P. Machado. Synthesis, Inhibition of Mycobacterium tuberculosis Enoyl-acyl Carrier Protein Reductase and Antimycobacterial Activity of Novel Pentacyanoferrate(II)-isonicotinoylhydrazones. Journal of the Brazilian Chemical Society (2017) With N.D.M. Sperotto, C.D. Roth, V.S. Rodrigues Jr., C.E. Neves et al. Design of novel inhibitors of human thymidine phosphorylase: synthesis, enzyme inhibition, in vitro toxicity and impact on human glioblastoma cancer. J. Med. Chem. 62(3):1231-45, 2019 BRAZILIAN AND FOREIGN PATENTS With P. Machado, L.A. Basso & K. Pissinate. Compound, method for producing the compound, pharmaceutical composition, use of the compound for preparing a medicinal drug for treating a disorder caused by bacteria of the genus Mycobacterium and method for treating a disorder caused by bacteria of the genus Mycobacterium BR1020150146809 & WO2016201541 A1 (2015) With L.A. Basso, P. Machado & D. Renck. Uso de 6-hidroxi-2-piridonas e seus derivados na preparação de uma composição farmacêutica que atue pela inibição da enzima uridina fosforilase humana (Use of 6-hydroxy 2 pyridones and derivatives thereof for preparing a pharmaceutical composition that act by inhibiting the human uridine phosphorylase enzyme ) BR10 2013022567-3 A232 (2013) & US9700547B2 (2014) With L.A. Basso, P. Machado & T.P. Gazzi. Method for synthesizing lanthanide-based coordination compounds, gadolinium (III)-based coordination compound and use of same BR102013023479-6 (2013) & WO2015035483A1 (2015) With E.L. Batista Jr., L.A. Basso, A.A. Souto, A.J. Donato & C. Deves. Deazapurinas, processo de preparo, composições farmacêuticas compreendendo deazapurinas e seu uso em osteoporose e/ou perda óssea,
Dimitri Sucre
Dimitri Ivan Sucre Benjamín, Panamanian-born Brazilian botanist and nurseryman (1935 – Rio de Janeiro 28 August 2000) DESCRIBED VALID PLANTAE SPECIES Dioscorea margarethia 1970 with Barroso & Guimarães Dioscorea pseudomacrocapsa 1971 with Barroso & Guimarães Dorstenia alberti 1974 with Carauta & Valente Dorstenia grazielae 1973 with Carauta & Valente Dorstenia milaneziana 1974 with Carauta & Valente Ferdinandusa edmundoi 1962 Malanea centralis 1963 Mitracarpus baturitensis 1971 Mitracarpus flagellatus 1969 Mitracarpus froesii 1971 Neoregelia lymaniana 1974 with Braga Pitcairnia burle-marxii 1971 with Braga Psylllocarpus psyllocarpoides 1971 Remijia cinchonicarpa 1962 Remijia grazielae 1962 Remijia hirsuta 1962 Remijia kuhlmannii 1962 Spermacoce egleri 1970 with Costa Spermacoce limae 1971 Spermacoce noronhensis 1969 Tillandsia grazielae 1975 with Braga Tillandsia nuptialis 1969 with Braga HONORS Sucrea Soderstrom 1981 (Poaceae)
Dezao Su
Dezao Su / Te Tsao Su, Chinese paleontologist (fl.1955-2011) DESCRIBED FOSSIL PISCES TAXA Families Peltopleuridae 1959 Siyuichthyidae 1985 Genera Asialepidotus 1959 Bogdaichthys 1985 Changichthys 1991 Chungkingichthys 1974 Ctenolepidotrichia 1992 with Poplin Dsungarichthys 1985 Fukangiichthys 1978 Jialingichthys 1983 Liaoxiichthys 1992 Manasichthys 1985 Neobaleiichthys 1985 Nieerkunia 1992 Plesiofuro 1992 Plesioperleidus 1983 with Li Shuniscus 1983 Sinoeugnathus 1959 Sinoglossus 1986 Siyuichthys 1980 Suziichthys 1992 Tianfuichthys 1996 Tianshanicus 2011 Triassodus 1984 Uighuroniscus 1985 Wayaobulepis 1999 Weixiniscus 1994 Yuchoulepis 1974 Zaxilepis 1994 Species Anathaelion longshanensis 1963 Asialepidotus shingyiensis 1959 Bogdaichthys fukangensis 1985 Bogdaichthys serratus 1985 Changichthys dalinghensis 1991 Chungkingichthys tachuensis 1974 Ctenolepidotrichia turfanensis 1992 with Poplin Dsungarichthys bilineatus 1985 Fukangiichthys longidorsalis 1978 Hemiculturellus longicephalus 1962 with Liu Jialingichthys serratus 1983 Lepidotes yaoanensis 1980 Lepidotes xinjinensis 1983 Lycoptera longicephalus 1963 with Liu Lycoptera lungteensis 1963 with Liu Lycoptera polyspondylus 1963 with Liu Lycoptera tungi 1963 with Liu Manasichthys elongatus 1985 Manasichthys tuguluensis 1985 Neobaleiichthys chikuensis 1985 Nieerkunia liae 1992 Palaeoniscinotus ningxuiaensis 1997 with Yuan & Deng Peltopleurus orientalis 1959 Perleidus yangtzensis 1981 Plesiofuro mingshuica 1993 Plesioperleidus dayeensis 1983 with Li Shuniscus longianalis 1983 Sinamia huananensis 1973 Sinamia poyangica 1990 with Li Sinoeugnathus kueichowensis 1959 Sinoglossus lushanensis 1986 Sinolepidotus longidorsalis 2003 Siyuichthys ornatus 1985 Siyuichthys pulchellus 1985 Suziichthys xinbiensis 1992 Tianfuichthys spinodorsalis 1996 Tianshanicus liui 2011 Triassodus yanchangensis 1984 Uighuroniscus sinkiangensis 1985 Wayaobulepis zichangensis 1999 Weixiniscus microlepis 1994 Wukangia huoyanshanensis 1985 Xenocypris yushensis 1962 with Liu Yuchoulepis szechuanensis 1974 Yuchoulepis gansuensis 1993 Zaxilepis qinglongensis 1994 HONORS (Fossil Pisces) Suius Liu 2002 Dezaoia Su, Chang & Chen 2021
Demetrio Sodi Pallares
Demetrio Sodi Pallares, Mexican cardiologist (Ciudad de Mexico 08 June 1913 – Ciudad de Mexico 12 August 2003) Authored over 150 papers and 18 medical and philosophical books ACHIEVEMENTS Established rational basis of practical electrocardiography Established many parameters for position analysis and myocardial performance With E. Cabrera, Vizcaíno & Soberón showed intracavitary potential in man and dog under normal conditions (1947) With Soberón, Estandía & Rodríguez first published intracavitary potential morphology of cardiac left ventricle With E. Cabrera enunciated the concept of endocardioelectric deductive electrocardiography With Zuckerman & Abdo Bisteni described electrocardiographic changes in acute pulmonary hypertensive cardiopathy With Gustavo Medrano, A. Bisteni & Alfredo de Micheli first described electrocardiograms with activation potentials in cardiac conduction system in dog in situ (1952) Enunciated concept of intraseptal barrier New bases of electrocardiography (1956) With A. Bisteni, Fishleder & G. Medrano described the physical basis of morphology of cardiac unipolar derivations (1959) Enunciated concept of electrical endocardium With G.A. Medrano & A. de Micheli. Unipolar QS morphology and Purkinje potential of the free left ventricular wall, the concept of electrical endocardium. Circulation 23:836-46, 1961 Developed poliparametric electrocardiography, a new electrocardiographic interpretation (1970) Authored Nuevas bases de electrocardiografia (1945) edited in United States and Italy Concluded that sodium retention in organic tissues give arise to many diseases (e.g. ischemic cardiopathy) Regarded as world pioneer on metabolic treatments and founder of modern magnetotherapy Introduced glucose-insulin-potassium infusion for treatment of acute myocardial infarction known as Sodi Pallares infusion (1962) With M.I. Rodríguez. Metodo para estudiar la secuencia y velocidad del proceso de activación en los ventrículos del perro. Valoración del metodo por el pronestyl (1952) Authored an important paper With F. Marsico. The importance of electrocardiographic patterns in congenital heart diseases. Am. Heart J. 49:202, 1955 HONORS Pavlov Medal, American Institute of Stress First Honorary President, Sociedad Española de Cardiologia (1964) Master Teacher, American College of Cardiology (1975) Honorary Member, Societé Française de Cardiologie (1977) Honorary Member, American Heart Association Sodi Award in Electrocardiography (1977) Osler Award (1976) EPONYMY Sodi Pallares sign Salazar-Sodi Pallares index
David Domingo Sabatini
David Domingo Sabatini, Argentine cytologist in United States (San Carlos de Bolívar, Buenos Aires Province 10 May 1931 – Regarded as one of the world’s leading scientists in the field of protein sorting in cells and membrane biogenesis Authored over 120 papers First reported Golgi apparatus involvement in the formation of chromaffin granules and the exocytotic character of catecholamines release from medullary cells Introduced glutaraldehyde as a new fixative for electron microscopy and cytochemical studies (1961) Performed classical studies on protein synthesis Discovered that the nascent polypeptide chain emerging from the large ribosomal subunit is responsible for the attachment of the ribosome to the endoplasmic reticulum membrane First suggested the mechanism that effects the insertion of proteins into membranes during the course of their synthesis Elucidated the cotranslational translocation of polypeptides in the endoplasmic reticulum With George E. Palade discovered how the neurons communicate with each other (1967) Developed a method which used puromycin to dissociate ribosomes into functionally viable ribosomal subunits (1970s) Discovered that a membrane-bound ribosome is held onto the membrane of endoplasmic reticulum With Gert Kreibich identified ribophorins, the first membrane proteins shown to be specific of rough endoplasmic reticulum membranes With G. Blobel formulated the signal hypothesis (1971). This research earned Blobel Medicine & Physiology Nobel Prize in 1999 With M. Cereijido introduced Madin-Darby canine kidney cell culture for the study of epithelial cell polarity (1970s) First reported the polarity of viral budding by epithelial cells With E. Rodríguez Boulan. Asymmetric budding of viruses in epithelial monolayers: a model system for study of epithelial polarity. Proc. Natl. Acad. Sci. USA 75:5071-5, 1978 Introduced many different methodologies to study translocation and the association of newly synthesized proteins within endoplasmic reticulum membranes (e.g. the use of protease as probes to demonstrate sequestration and of dilute detergents to extract the translocated chains found with the microsomal contents) HONORS Samuel Roberts Noble Research Recognition Award (1980) Grand Medaille d’Or, Academie Française des Sciences (2003) LINKS http://legacy.library.ucsf.edu/tid/vjm36b00;jsessionid=F0D124B9E7F07A8FD2AC3C98AB97C038.tobacco03