Antonio Carlos Martins de Camargo
Antonio Carlos Martins de Camargo, Brazilian biochemist (São Carlos, São Paulo State 19 January 1937 – Authored over 190 papers Isolated and characterized two peptidases correspondent to a new class of proteases (EOPA/NUDEL and Prolyloligopeptidase) and the first kininases from nervous tissue With R. Shapanka & L.J. Greene. Preparation, assay and partial characterization of a neutral endopeptidase from rabbit brain. Biochem. 12:1838-44, 1973 With E.B. Oliveira & A.R. Martins. Isolation of brain endopeptidases: influence of size and sequence of substrates structurally related to bradykinin. Biochem. 15:1967-74, 1976 Isolated and characterized the precursor of bradykinin-potentiating peptides and C-type natriuretic peptides from snake venom Named oligopeptidase With H. Caldo & M.L. Reis. Susceptibility of a peptide derived from bradykinin to hydrolysis by brain endo-oligopeptidases and pancreatic proteinases. J. Biol. Chem. 254:5304-7, 1979 With colleagues isolated new peptides (at least 21) from snake and anuran venoms such as bothrostatin (2005), SIKVAV (2007) and crotalphine (2008), this last is a potent analgesic DEVELOPED METHODS With K.M. Carvalho, G. Boileau & L. Camargo. A highly selective assay for neutral endopeptidase based on the cleavage of a fluorogenic substrate related to leuenkephalin. Biochem. 237:167-73, 1996 With K.M. Carvalho, G. Boileau, M.S.F. França, M.A.S. Medeiros & L. Juliano. A new fluorimetric assay for neutral endopeptidase (EC3.4.24.11). Braz. J. Med. Biol. Res. 28:1055-9, 1995 With A.C. Spadaro, W. Draghetta, S. Nassif & L.J. Greene. Convenient manual trinitrobenzenesulfonic acid method for monitoring amino acids and peptides in chromatographic column effluents. Anal. Biochem. 96:317-21, 1979 PATENTS Brazilian With M.A.F. Hayashi, F.C.V. Portaro, A.F. Murbach, D.A. Ianzer, S.H. P. Farsky & M.S. Palma. Processo de isolamento e purificação de peptídeos inibidores das vasopeptidases, com especificidade para o sítio carboxílico da enzima conversora da angiotensina, secretados pelas glndulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptídios inibidores secretados pela glandula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores PI 0101088-3 A2 (2001) With M.A.F.Hayashi, F.C. V. Portaro & J.R. Guerreiro. Processo para a determinação da estrutura primária do rna mensageiro codificante para a endooligopeptidase humana recombinante – a heopa e da sua seqüencia protéica, para a determinação de gene da eopa humana e para a produção da eopa humana recombinante; processo de geração de anti-corpo anti-eopa humana policlonais e em camundongos; processo de caracterização e substratos sintéticos das propriedades bioquímicas e proteolíticas da eopa e anticorpos inibidores da atividade catalítica e de interação com oligopeptídeos; competidores e antagonistas; método de identificação de condições de patologia PI 0205000-5 A2 (2002) With M.A.F.Hayashi, F.C. V. Portaro & & J.R. Guerreiro. Processo para a determinação da estrutura primária do rna mensageiro codificante para a endooligopeptidase a humana (heopa) [genbank acc nºaf217798] e da sua seqüência protéica [genbank acc nº aaf24516], para a determinação do gene da eopa humana, e para a produção da eopa humana recombinante; processo de geração de anticorpos anti-heopa; processo de padronização e utilização de substratos sintéticos para a determinação das propriedades bioquímicas e proteolíticas da heopa; processo de identificação e produção de inibidores da eopa, obtenção de anticorpos com atividade inibitória sobre a atividade … PI 0305688-0 A2 US20070031830A1 (2002) With R.D. S. Millán & R.A.S. dos Santos. Composições farmacêuticas de peptídeos, secretados pelas glândulas do veneno de serpentes, particularmente da bothrops jararaca, inibidores de vasopeptidases, evasins, seus análogos, derivados e produtos associados para o desenvolvimento de aplicações e uso em doenças crônico-degenerativas PI 0205449-3 A2 (2002) With R.A.S. dos Santos & R.D.S. Millán. Processo de separação de formulações farmacêuticas e/ou produtos associados, para o desenvolvimento de aplicação dos EVASINS e seus análogos estruturais e/ou conformacionais em doenças crônico-degenerativas (2002) With F.C.V. Portaro & J.R. Guerreiro. Endooligopeptidase A (EOPA) 2003 With M.A.F.Hayashi, A.H. Ulrich, R.D. S. Millán, R.A.S. dos Santos, D.A. Ianzer & R. R. Marioni. Composições farmacêuticas de peptídeos, secretados pelas glndulas do veneno de serpentes, particularmente da bothrops jararaca, evasins, seus análogos, derivados e produtos associados para uso como agentes moduladores dos receptores de acetilcolina PI 0400192-3 A2 (2004) With P. Brigatte, Y. Cury, G. Picolo, K. Konno, R. Giorgi & V.P. Gutierrez. Compostos análogos a peptídeos analgésicos derivados de veneno de serpentes crotalus durissus terrificus, seus usos, composições, métodos de preparação e de purificação PI 0502399-8 A2 (2004) With Y. Cury, G. Picolo & K. Konno. Processo de síntese e composições farmacêuticas de peptídeos e análogos derivados do veneno de serpentes, por exemplo, do gênero Crotalus, com atividade analgésica, usos e produtos associados (2005) With R.L. Melo, M.A.F.Hayashi, J.R. Guerreiro, D.A. Ianzer, C.A. da Silva, C.L. Gomes & O. Augusto. Peptídeo rico em prolina, composição farmacêutica, uso de um ou mais peptídeos PI 0600331-1 A2 (2006) With D.A. Ianzer, C.A. da Silva, C.L. Gomes & J.R. Guerreiro. Oligopeptídeo rico em prolina, composição farmacêutica, uso de um ou mais peptídeos e método de tratamento PI 0607366-2 A2 (2006) Patente nº BR 20 2012 014822 1 (2012) Foreign Process for the determination of the primary structure of the Messenger RNA coding for the human recombinant endooligopeptidase a (HEOPA) (af217798) Pharmaceutical compositions of peptides secreted by the venom glands of snakes. WO2005081613A2 (2005) Isolation and purification procedure of vasopeptidases inhibitors US20050031604A1 (2005) Proline-rich peptides, pharmaceutical composition, use o fone or more peptides and method of treatment WO2007079558A2 & EP1979373A2 (2007) Pharmaceutical compositions, preparation of peptides secreted by the snake venom glands, particularly of Bothrops jararaca, vaso-peptidases inhibitors , evasions, their analogues, derivatives and products associated, thereof, for development of applications and use in chronic-degenerative diseases. US20080199503a1 (2008) Analog compounds of analgesic peptides derived from the venom of Crotalus durissus terrificus snake, their uses, compositions, methods of preparation and purification US20090203618A1 (2009)
Antonio Carini
Antonio Carini, Italian / Brazilian microbiologist and parasitologist (Sondrio, Lombardy Region 17 September 1872 – Milano 09 April 1950) ACHIEVEMENTS Described lamellar ichthyosis or Carini syndrome Di una forma attenuate della cosidetta “ittiosi sebacea” (I. lamellare). Giorn. Ital. delle Malad. Ven. Pelle 82, 1895 Demonstrated that swine croup (garrotilho dos porcos) is blood anthrax (1909) Described a generalized mycosis in frogs and toads analogous to verrucous dermatitis Sur une moissisure qui cause une maladie spontane de Leptodactylus pentadactylus. Ann. Pasteur (1910) With Parreiras Horta discovered that bats can transmit rabies (1911). This fact was confirmed by German scientists in 1914 Sobre a epizootia da raiva observada no Estado de Santa Catarina. Morcegos propagadores da moléstia. Chácaras e Quintaes 3(6), 1911 First to report natural toxoplasmosis of birds (1911) Discovered causative agent of pulmonary tuberculosis in mice (Carini pneumonia) that was named Pneumocystis carinii in his honor (1912) Identified Leishmania brasiliensis (1909) independent of Lindemberg With A. Lindemberg established procedures for laboratorial diagnosis of leishmaniasis Showed the epidemic paronychia as a special localization of tropical ulcer Oxonyxis ulcereux phagédénique. Bull. Soc. Path. Exot. 10 (1915) Determinated arsenic-based treatment for bovine piroplasmosis Proved the beneficial action of quinine hydrochloride on skin lesions of amebiasis DESCRIBED PROTOZOAN TAXA Valid Genera Bertarellia 1930 Brumptina 1933 Dermosporidium 1940 Pintospora 1944 Rangelia 1915 with Maciel Species 86
Antonio Brito da Cunha
Antonio Brito da Cunha, Brazilian geneticist (São Paulo 17 June 1925 – Brasilia 02 December 2019) Proposed the adaptive polymorphism (genetic variability correlated to degree of ecological diversity of environment that species live) With H. Burla & T. Dobzhansky. Adaptive chromosomal polymorphism in Drosophila willistoni. Evolution 4(3):212-35, 1950 Others Developed a cage for Drosophila populations Genetic analysis of the polymorphism of color pattern in Drosophila polymorpha. Evolution 3:239-51, 1949 With W.E. Kerr. A genetical theory to explain sex determination by arrhenotokous parthenogenesis. Forma et Functio 1:33-6, 1957 Developed a method for chromosomal analysis taking account the location of lethal factors and its interrelationships With L.E. Magalhães & J.S. Botelho. The nature of lethals in Drosophila willistoni. Genetics 53:559-608, 1965 Presented a model of chromosome structure for explaining how the genetic redundance could origin and how DNA produced in excess could be related to chromosome With C. Pavan. Gene amplification in ontogeny and phylogeny of animals. Genetics 61 (Suppl): 289-304, 1969 Developed methods for maintenance of Dipteran Sciaridae With J.S. Morgante, J. Marques & I. Romeo. Métodos para a criação de alguns Sciaridae (Diptera). Rev. Bras. Entomol. 14:33-40, 1970 With T. Dobzhansky With O. Pavlovsky & B. Spassky. Genetics of natural populations. XXVIII. Supplementary data on the chromosomal polymorphism in Drosophila willistoni in its relation to the environment. Evolution 13:389-404, 1959 With C. Pavan. Heterosis and elimination of weak homozygotes in natural populations of three related species of Drosophila. Proc. Natl. Acad. Sci. USA 43(2):226-34, 1957 Differentiation of nutritional preferences in Brazilian Drosophila. Ecology 36:34-9, 1955 A further study of chromosomal polymorpphism in Drosophila willistoni in its relation to the environment. Evolution 8:119-34, 1954 With A. Sokoloff. On food preferences of sympatric species of Drosophila. Evolution 5:97-101, 1951 With H. Burla. A comparative study of chromosomal polymorphism in sibling species of the willistoni group of Drosophila. Am. Nat. 89:229-46, 1950 With H. Burla, A.G.L. Cavalcanti & C. Pavan. Population density and dispersal rates in Brazilian Drosophila willistoni. Ecology 31(3):393-404, 1950 With H. Burla, A.R. Cordeiro, C. Malagolowkin & C. Pavan. The willistoni group of sibling species of Drosophila. Evolution 3(4):300-14, 1949 Papers in Nature Chromosomal inversions with sex-limited effects. Nature 172:815, 1953 A further analysis of the polymorphism of Drosophila polymorpha. Nature 171:887, 1953 Papers made to order Chromosomal polymorphism in Diptera. Advanc. In Genet. 7:93-138, 1955 Chromosomal variation and adaptation in insects. Ann. Rev. Entomol. 5:85-110, 1960 With C. Pavan, Chromosomal activities in Rhynchosciara and other Sciaridae. Ann. Rev. Genetics 3:425-50, 1969 NEW SPECIES Diptera Drosophila arapuan 1947 with Pavan Drosophila ararama 1947 with Pavan Drosophila arassari 1947 with Frota-Pessoa Drosophila (Sporophora) bocainensis 1947 with Pavan Drosophila bromelioides 1947 with Pavan Drosophila caponei 1947 with Pavan Drosophila (Sporophora) tropicalis 1949 with Burla Protozoa Schneideria schmeiderae 1975 with Morgante, Malavasi, Marques & Garrido
Antonio Barros de Ulhoa Cintra
Antonio Barros de Ulhoa Cintra, Brazilian internist and endocrinologist (São Paulo 13 September 1907 – São Paulo 23 December 1998) DESCRIBED NEW SYNDROMES Described a new disease entity, a variation of Fanconi syndrome, characterized by lack of the glycosuric element in his thesis Doenças Osseas Metabólicas (1949) Reported the first case in the literature of the incidence in the male With A.L. de Almeida, H.L. de Oliveira & E. Mattar. Syndrome characterized by nanism, gonadal insufficiency and congenital deformities with normal function of the anterior pituitary. Arq. Clin. 10(2-3):94-102, 1950 Described a syndrome of amenorrhoea, galactorrhoea and primary hypothyroidism With A.R. Hennes &B.L. Wajchenberg. A syndrome characterized by hypothyroidism and galactorrhea. Port. Med. 44:693-702, 1960 With G.A. Medeiros Neto & J.A. Levy. Congenital hypothyroidism with dishormogenesis accompanied by muscular hypertrophy. Acta Endocr. Panam. 3:79, 1972 DEVELOPED METHODS With I. Martirani, G. Hoxter, B.L. Wajchenberg & I. Marian. Determination of polyssacharide hexoses and hexosamines in normal human sera. J. Lab. Clin. Med. 54:773-8, 1959 With M. Sato. Simple and rapid method for the determination of pituitary gonadotropins in urine. Rev. Assoc. Med. Bras. 9:153-6, 1963 With F.B. de Jorge. Contribution to the study of the metabolism of nitrogenous substances. II. Rapid and precise method for determination of urea in biological fluids (blood, cerebrospinal fluid, urine and saliva). Rev. Paul. Med. 62:289-97, 1963 With A.G. Silva & F.B. de Jorge. Determinação quantitativa do enxofre nos materiais biológicos. Rev. Bras. Med. 21: 491-4,1964 (a turbidimetric procedure for carrying out sulfur determinations) With F.B. DeJorge & A.G. Silva. Determinação quantitativa de magnésio nos materiais biológicos. Rev. Paul. Med. 64:224-36, 1964 With W. Nicolau, E. Muramoto, L.M. Assis & R.R. Pieroni. Metodo de dosagem do acido 3-metoxi-4 hidroximandélico na urina por técnica cromatográfica monodimensional. Rev. Assoc. Med. Bras. 15:215, 1969 Papers in top journals With A. Borelli, M.O. Leite & I. Mariani. Carbohydrates in the non-dialysable fractions of filtered urine in hyperparathyroidism. Lancet 1 (7276):290-2, 1963 SOME BIBLIOGRAPHY With A. Borelli, M.O. Ribeiro Leite, P.H.S. Correa aet al. Bone histomorphometry in Cushing’s syndrome. J. Endocrinol. Invest. 15:783-7, 1992 With G.A. Medeiros Neto & W. Bloise. Partial defect of iodide trapping mechanism in two siblings with congenital goiter and hypothyroidism. Clin. Endocrinol. Metab. 35:370, 1972 Wioth S.P.A. Toledo, P.H. Saldanha & A. Borelli, Further data on acheiropody. J. Genet. Hum. 20:253-8, 1972 With B. Wajchenberg, E.R. Quintão & B. Liberman. Antagonism between adrenal steroids and parathyroid hormone. J. Clin. Endocrin. Metab. 25(12):1677-81, 1965 With F.B. DeJorge, P.E. Haesser, A.S.F. Ditadi, J.A. Petersen & P. Sawaya. Biochemical studies on the giant earthworm Glossoscolex giganteus. Comp. Biochem. Physiol. 16:491-6, 1965 With F.B. DeJorge, J.S. Góes & A.B. Guedes. Biochemical studies on copper, copper oxidase, magnesium, sulfur, calcium and phosphorus in cancer of breast. Clin. Chim. Acta 12:403-6, 1965 With F.B. DeJorge, P.E. Haeser & P. Sawaya. Biochemical studies on the snail Strophocheilus oblongus musculus (Bequaert). Comp. Biochem. Physiol. 14:35-42, 1965 With F.B. DeJorge, D. Delascio & M.L. Antunes. Magnesium concentration in the blood sérum of normal pregnant women. Obstet. Ginecol. 25:253, 1965 Disorders of copper metabolism in epilepsy. Acta Neurol. Scand. 40:97-106, 1964 With B.L. Wajchenberg, V.S. Pereira, A.A. Pupo, J. Schnaider & E. Mattar. On the mechanism of insulin hypersensitivity in adrenocortical insufficiency. Diabetes 13:169-76, 1964 With E.H.L. Melo, I.M. Melo, A.C. Neto et al. Glycoprotein metabolism with special reference to mucoids in hypo and hyperthyroidism. J. Clin. Endocrin. Metab. 23:561, 1963 With L.C. da Silva, M.A. Jamra, V. Maspes, J.F. Pontes & R.R. Pieroni. Pathogenesis of indirect reacting hyperbilirubinemia after portacaval anastomosis. Gastroent. 44:117-24, 1963 With E. Mendes, V. Amato Neto, D.O. Penna & J.A. Meira. Pneumopatia alérgica eosinofilica. O Hospital 59:11, 1961 With B.L. Wajchenberg, V.G. Pereira, J. Schneider, L.M. Assis & S.A. Sampaio. Addison’s disease associated with South American blastomycosis. Ann. Intern. Med. 5:139, 1961 With J. Cruz, H.M.M. Cruz, S.E. Almeida & F.B. DeJorge. Valores normais da prova de concentração urinária. Rev. Paul. Med. 57:282, 1960 With V.G. Pereira & D. Marinelli. Criptococose disseminada (Torulose). Considerações acerca de um caso atípico. Rev. Hosp. Clin. Fac. Med. S. Paulo 12:455-8, 1957 With J. Czapski, M.O. Ribeiro Leite, D. O. Penna & T. Fujioka. Cianosis in Manson’s schistosomiasis. Role of pulmonary schistosomotic arteriovenous fistula. Am. Heart J. 54(2):196-204, 1957 With B.L. Wajchenberg, G. Hoxter, J. Segal et al. Electrophoretic patterns of the plasma proteins in diffuse liver necrosis. Gastroenterol. 30:882-93, 1956 With H.L. Oliveira, Y. Rapp, E. Mattar & E.M. Russo. Sobre um caso de osteíte fibrosa disseminada. Arq. Clin (1947) Contribuição para o estudo da exploração funcional do fígado. Thesis (1940) Sobre a imunidade natural à difteria. Doctoral Thesis (1931) With W. Bloise, W. Nicolau, B.L. Wajchenberg, R.R. Pieroni et al. Thyrotoxic crisis and electrolyte disturbances in a patient with functioning metastatic carcinoma of the thyroid With A.L. Almeida, I. Rapoport & A.M. Leite. Esplenoportografia e manometria por via percutânea.
Antenor Leitão de Carvalho
Antenor Leitão de Carvalho, Brazilian zoologist (Barreira do Piquete, São Paulo State 15 April 1910 – Rio de Janeiro 11 December 1985) DESCRIBED VERTEBRATE TAXA Amphibia Genera Arcovomer 1954 Hamptophryne 1954 Hyophryne 1954 Macrogenioglottus 1946 Myersiella 1954 Paratelmatobius 1958 with Lutz Relictivomer 1954 Synapturanus 1954 Species Arcovomer passarellii 1954 Hyophryne histrio 1954 Macrogenioglottus alipioi 1946 Paratelmatobius lutzii 1958 with B. Lutz Rhinella dapsilis 1945 with Myers Rhinella pygmaea 1952 with Myers Pisces Genera Sartor 1959 with Myers Simpsonichthys 1959 Species Simpsonichthys boitonei 1959 Simpsonichthys bokermanni 1987 with da Cruz Simpsonichthys myersi 1971 Fluviphylax pygmaeus 1955 with Myers Sartor respectus 1959 Reptilia Species Anolis phyllorhinus 1945 with Myers Siagonodon cupinensis 1946 with Bailey Subspecies Caiman latirostris chacoensis 1965 with Freiberg HONORS Carvalhodesmus Schubart 1945 (Myriapoda)
Anisio Campos
José Anisio Barbosa de Campos, Brazilian automobile designer (São Paulo 06 March 1933 – São Paulo 14 September 2019) Designed Puma models (GT, DKW & UW) that was the first Brazilian vehicle to be sold abroad to more than 50 countries The only model of a Brazilian company to be manufactured under license in another country (South Africa in 1973) The one national brand car on display at Volkswagen Museum at Wolfsburg, Germany DESIGNED CAR MODELS Puma GT DKW (1964) Carcará (1966) with Rino Malzoni (died 1979) & Jorge Lettry Simca Xangô (1966) AC biposto de corrida (1968) Puma GT 4R (1969) Karmann-Ghia Porsche (1960s) Kadron Tropi (1970) AC Vê (1974) with M. Crispim & H.P. Martinez Buggy Kadron (1979) Corcel Hatchback (1980) Dacon 828 (1982) Pag Dacon (1984) with P.A. Goulart Nick Dacon (1984) Escorpion Ergo-cabine & pick-up (1985) Engerauto Topazzio (1987) PAG Nickinho & Nickão (1988) Chubby (1990) 82812 (2003) Obvio! O12 (2005)