Ricardo Bressani Castignoli
Ricardo Bressani Castignoli, Guatemalan food expert (Ciudad de Guatemala 28 September 1926 – Ciudad de Guatemala 30 January 2015) Authored over 500 publications between papers, monographs, book chapters and conference memoirs Discovered that certain coumponds found in soybean help digestive processes in man Developed cotton, legume, platan and cereal flours such as Incaparina (1959), Vitatol, Bienestarina and Innovarina Developed other food products like cookies HONOURS Babcock Hart Award, Institute of Food Technologists, USA (1970) McCollum Award, American Society of Clinical Nutrition (1971) Doctor Honoris Causa, Purdue University (1976) Albert Einstein World Award of Science, World Cultural Council (1984) Danone International Prize for Nutrition (2003) Guest Researcher, Rutgers State University & Massachusetts Institute of Technology
Ramchandra Kashinath Bhide
Ramchandra Kashinath Bhide, Indian economic botanist (fl.1912-35) SOME CONTRIBUTIONS With S.G. Bhalerao. The Kolamba rice of the North Konkan and its improvement by selection. India Dept. Agr. Mem. Bot. Ser. 14:199-245, 1927 With S. G. Bhalerao. Correlation studies in rice. Mem. Dept. Agric. Ind. 14(7):78-83, 1927 Inheritance and correlation of certain characters in rice crosses. Poona Agric. Col. Mag. 18:76-85, 1926 A cause of sterility in rice flowers. Agr. Jour. India 17:584-6, 1922 Two important problems in rice and how to solve them. Poona Agric. Coll. Mag. 11:33-6, 1919 Preliminary note on the study of the rice varieties. Poona Agr. Col. Mag. 5:286-90, 1914 DESCRIBED PLANTAE SPECIES (1912) Chloris quinquesetica Danthonidium gammiei Dichantium paranjpyeanus Enteropogon badamicus Sporobolus scabrifolius Tripogon roxburghianus HONORS Bhidea Stapf ex Bor 1948 (Poaceae)
Raj Chandra Bose
Raj Chandra Bose, Indian mathematician and statistician in United States (Hoshangabad, Madhya Pradesh 19 June 1901 – Fort Collins, Colorado 31 October 1987) Regarded as a founder of mathematical basis for experimental design With D.K. Ray-Chaudhuri and independent of Hocquenghem invented BCH codes (1960) With S.S. Shrikhande constructed a Greek-Latin square of size 10 disproving a 1782 Euler conjecture (1959) Introduced Bose-Mesner algebra (1959) With T. Shimamoto coined the term association scheme (1952) Invited Lecturer, International Congress of Mathematicians (1950) Eponym of Bose theorem (1934), Bose distribution (1935) and Bose-Burton theorem (1966)
Raimundo Braz Filho
Raimundo Braz de Souza Filho, Brazilian natural products chemist (Pacatuba, Ceará State 19 April 1935 – Obtained rufescidride, a new arylnaphthalene type lignan and the first containing an unusual anhydride moiety (2004) With C.R.S. Feitosa, R.C. Silva, J.E.S. A. Menezes et al. reported new ceramides for the first time in Cucurbitaceae (2011) With D. Oevstedal, T. Fossen, R.G. Oliveira Jr, A.P. Oliveira et al. isolated the first flavonoid from Bromeliaceae Family ((2014) DISCOVERED NEW COMPOUNDS (incomplete list) A new type of chalconoid dimers (2003) Darcyribeirine, a pentacyclic indole alkaloid (2002) Velloziolide, a diterpene with a novel skeleton (1982) Muscicapines, a class of guaiane-type sesquiterpene alkaloids (2005) Diploflavone, a flavonoid (2005) Trichotomol, a cadinenediol (2001) Hirtinone, a cycloartane-type triterpene (2013) Lepidotrichilins, protolimonoids (2013) Maytensifolone, a triterpene (2013) Aplysfistularine, a dibromotyrosine derivative (2012) Palyosulfonoceramides, sulfonylated ceramides from zoanthids (2012) Simiranes, diterpenes (2011) Pungecine, tropane alkaloid (2010) Spruceanumines, plumeram indole alkaloids (2009) Cymosamine, a C19 quassinoid (2005) Bowdichinia, a diaga-adamantane alkaloid (2004) Bowdenol, 2,3-dihydrobenfuran (2001) 7-epiclusanone, tetraprenylated benzaphenone (1999) Glaziovianol, terpenoid hydroquinone (1999) Botocudorol, bisabolene type nor-sesquiterpene (1991) Vismiaefolic acid, triterpene (1990) Sonderianin, furanoid diterpene (1981) Compactone, diterpenoid (1979) Laevigatin, sequiterpenoid (1978) Porosin, neolignan (1973) With W.B. Eyton. O.R. Gottlieb & M. T. Magalhães. A química de leguminosas brasileiras. XII. As apuleínas, flavona-hepta oxigenadas da Apuleia leiocarpa. An. Acad. Bras. Cien. 40(1):23-7, 1968 DEVELOPED PROCESSES/TECHNIQUES Improved an electrophic aromatic thallation of phenol ethers (1986) With T.C.A.B. Leal, S.P. Freitas & J.F. Silva. Simplified laboratory extraction of lemongrass essential oil by steam distillation. Ceres 48:717-22, 2001 With M. Faccione, D.T. Ferreira, H.O. Saradakis et al. A new method for asperphenamate synthesis and its antimicrobial activity evaluation. Natural Product Reports 20:537-41, 2006 BRAZILIAN PATENTS With H.S. Abreu. Isolation method of nor-triterpene from Lophanthera lactescens presenting pharmacological activity. Number 04007 (1999) HONOURS International Award of Recognition, American Biographical Institute (1995) International Cultural Diploma of Honor, American Biographical Institute (1995) International Leader in Achievement, International Biographical Centre, Cambridge (1995)
Rafael Barahona Andrade
Rafael Barahona Andrade, Ecuadorian physician and surgeon (Quito 30 September 1827 – Quito 01 March 1898) ACHIEVEMENTS Created Barahona draught (tonic) and Indian draught (against paludism). Devised a continuous extension and counterextension apparatus for femur fractures (1853). This apparatus arrived France in 1894 where was commended highly by Paul Jules Tillaux. See http://www.diccionariobiograficoecuador.com/tomos/tomo14/b3.htm (in Spanish)
Radovan Borojevic
Radovan Borojevic, Croatian-born Brazilian morphologist and developmental biologist (Varazdin 16 November 1940 – Established the presence of one ancestral system of totipotent stem cells in cellular differentiation in Porifera Etude experimentale de la differentiation des cellules de l’eponge au cours de son developpement. Devel. Biol. 14:130-53, 1966 Recognized as a world reference in Calcarea class described and named 7 families, 10 genera and 34 valid species of Porifera With A.N. Monteiro, S.A. Vinhas, G.B. Domont, P.A. Mourão et al. Establishment of a continuous cell line from fibrotic schistosomal granulomas in mice livers. In vitro Cell. Dev. Biol. 21(7):382-90, 1985 With S.A. Vinhas, A.N. Monteiro, G.B. Domont et al. Liver connective tissue cells isolated from human schistosomal fibrosis or alcoholic cirrhosis represent a modified phenotype of smooth muscle cells. Bio Cell. 53(3):231-8, 1985 Proposed a method for quantification of anchorage-dependent cells in culture on plane surfaces or on microcarriers With R. Margis. Quantification of attached cells in tissue culture plates and on microcarriers. Anal. Biochem. 181(2):209-11, 1989 With L.C.F. Silva & P.A.S. Mourão. Identification of a cell responsible for synthesis of sulfated-glycosaminoglycan in schistosome-induced granulomas. Int. J. Exp. Path. 71:845-56, 1991 Experimental murine schistosomiasis mansoni. Establishment of the chronic phase of the disease. Mem. Inst. Oswaldo Cruz 87(Suppl 4):171-4, 1992 First biochemical description of the proteoglycans produced by a liver connective tissue cell line derived from schistosomal granulomas With L.C. Silva & P.A. Mourão. Membrane-associated and secreted proteoglycans from a continuous cell line derived from fibrotic schistosomal granulomas. Biochim. Biophys. Acta 1138(2):133-42, 1992 With C.B. Palatnik, E.P. de Souza et al. Transmission of visceral leishmaniasis by blood transfusion in hamsters. Braz. J. Med. Biol. Res. 29(10):1311-5, 1996 With M.R. Custodio, I. Prokic, R. Steffen et al. Primmorphs generated from dissociated cells of the sponge Suberites domuncula: a model system for studies of cell proliferation and cell death. Mech. Ageing Dev. 105 (1-2):45-59, 1998 First to analyze a promoter of a sponge gene for its activity in a heterologous cell system from higher Metazoa With C.C. Coutinho, J. Seack, G. Van de Vyver & W.E. Muller. Origin of the metazoan bodyplan: characterization and functional testing of the promoter of the homeobox gene Em H-3from the freshwater sponge Ephydatia muelleri in mouse 3T3 cells. Biol. Chem. 379(10):1243-51, 1998 With L.M. Alves, C.C. Werneck, R.R.C. Martins et al. A continuous lineage of rat adenohypophysis stromal cells: characterization and effects on GH(3)B(6) prolactin-secreting cell behavior. Biol. Cell 94(7-8):519-33, 2002 First clinical trial in the world to use stem cells to regenerate heart muscle With E.C. Perin. H.F. Dohmann, S.A. Silva & A.L. Silva. Transendocardial, autologous bone marrow cell transplantation for severe chronic ischemic heart failure. Circulation 107:2294-302, 2003 Proposed the existence of cartilage-derived progenitor cells Proposed that hepatic stellate cells represent a particular cell population specialized in storage of lipi-soluble substances With C.V. Rodrigues, P. Serricella, A.B. Linhares et al. Characterization of a bovine-collagen hydroxyapatite composite scaffold for bone tissue engineering. Biomaterials 24(27):4987-97, 2003 First report of a multicellular prokaryotic organism that proliferates by dividing into two equal multicellular organisms each similar to the parent one With C.N. Keim, J.L. Martins, F. Abreu, H. Lins de Barros et al. Multicellular life cycle of magnetotactic prokaryotes. FEMS Microbiol. Lett. 240(2):203-8, 2004 First murine cholangiocyte cell line isolated from schistosomal fibrosis reported in the literature With L.B. Chiarini. C.M. Takiya & A.M. Monteiro. Long-term culture of cholangiocytes from liver fibro-granulomatous lesions. BMC Gastroenterol. 6:13, 2006 Reported the first case of intra-arterial autologous bone marrow mononuclear cell transplantation for acute ischemic stroke With M.L. Mendonça, G.R. Freitas, S.A. Silva, H.F. Dohmann et al. Safety of intra-arterial autologous bone marrow mononuclear cell transplantation for acute ischemic stroke. Arq. Bras. Cardiol. 86(1):52-5, 2006 First to describe an in vitro model of fibrosis, hypertrophy and remodeling induced by Trypanosoma cruzi in cardiomyocyte spheroids With L.R. Garzoni, D. Adesse, M.J. Soares et al. Fibrosis and hypertrophy induced by Trypanosoma cruzi in a three-dimensional cardiomyocyte culture system. J. Infect. Dis. 197(6):906-15, 2008 With L. Baptista, R.J.C. do Amaral, R. Carias et al. An alternative method for the isolation of mesenchymal stromal cells derived from lipoaspirate samples. Cytotherapy 11:706-15, 2009 With A.J. Theodoro, D. Perrone & R.B. Martucci identified hepatic stellate cells are able to store and isomerise lycopene (2009) With R.J. do Amaral, C.S. Pedrosa, M.C. Kochem, L.S. Baptista et al. isolated human nasoseptal chondrogenic cells and proposed that they maybe a possible source cartilage tissue engineering and a model for studies of chondrogenesis (2012) Proposed a 3D co-culture system where gastric epithelia and stromal cells are grown together building spherical and solid structures With C.A. Santos, L.R. Andrade, M.H. Costa et al. Gastrospheres of human gastric mucosa cells: an in vitro model of stromal and epithelial stem cell niche reconstruction. Histol. Histopathol. 31(8):879-95, 2016 BRAZILIAN PATENTS With C.B. Palatnik. Processo de obtenção, extração, purificação e distinção de fml do extrato aquoso de promastigotas de L. donovani ld1s e uso de antígeno fml e das frações extraídas e definidas na sua totalidade ou qualquer de suas subfrações para a preparação de reagentes usados em imunodiagnóstico, controle de qualidade para leishmaniose no sangue utilizado para transfusão, transplante de órgãos, acompanhamento de tratamento de leishmaniose em humanos ou animais, em vacinação ou qualquer outro tratamento visando a imunoproteção ou imunoterapia da leishmaniose em animais ou humanos PI1100173-9 B1 (1997) With C.B. Palatnik. Composição contendo frações de células de Leishmania, denominadas antígenos fml “fucose mannose ligand” ou ligante de fucose-mannose, uso do antígeno fml e de suas subfrações e componentes para as aplicações em imunodiagnóstico específico da leishmaniose visceral humana e animal para aplicações em vacinação, tratamento ou imunoterapia contra a leishmaniose visceral humana e canina. PI9302386-3 A2 (1993) HONORS His doctoral thesis was awarded by Developmental Biology Society Genus Borojevia Klautau, Azevedo, Condor-Luján, Rapp, Collins & Russo 2013 (Porifera)