Ricardo Renzo Brentani
Ricardo Renzo Brentani, Italian-born Brazilian clinical biochemist (Trieste, Friuli-Veneza Giulia 21 July 1937 – São Paulo 29 November 2011) From Italian, Jewish and Austrian ancestry Performed studies on cancer biochemistry and cytology Authored about 200 papers with more than 5,000 citations DISCOVERIES/METHODS Demonstrated the presence of messenger RNA in nucleolus With I. Raw & M. Brentani. Role of nucleolar ribonucleic acid in incorporation of ribosomal amino acid. Nature 201:1130, 1964 With G. Vignolas & L.C.U. Junqueira. A simple and sensitive method for the quantitative estimation of collagen. Anal. Biochem. 94:96-9, 1979 Developed Picrosirius polarization method or Junqueira staining With G. Vignolas & L.C.U. Junqueira. Picrosirius staining of polarization microscopy, a specific method for collagen detection in tissue sections. Histochem. Journal 11: 447-55, 1979 Demonstrated the collagen macromolecular orientation in basement membrane With L.C.U. Junqueira, G.S. Montes, O.M.S.Toledo et al. Evidence for collagen molecular orientation in basement membranes. Histochem. J. 15:785-94, 1983 Showed the presence of laminin receptors in membrane of pathogenic Staphylococcus First to show how Staphylococcus aureus promoted abscesses at distance (later it has been reported the same mechanism for other pathogenic organisms) With J.D. Lopes & M. dos Reis. Presence of laminin receptors in Staphylococcus aureus. Science 229 (4710):275-7, 1985 With C.R.M. Barardi, C.L.S. Santos & L.L. Villa. A direct method for cDNA cloning employing translation-released mRNA. Brazilian Journal of Medical and Biological Research 20:313-320, 1987 Developed the complementary hydropathy theory (launched by Jan Biro in 1981) Biological implications of complementary hydropathy of amino acids. J. Theor. Biol. 135:495-9, 1988 With V.R. Martins, E. Graner, J. Garcia Abreu, S.J. de Souza & V.M. Neto. Complementary hydropathy identifies a cellular prion protein receptor. Nature Med. 3:1376-81, 1997 With V. Martins, S. Souza & V. Moura Neto found that prion controls and organizes the information passing from outer to inner cell With P.J. Mintz, M. Cardó-Vila, M.G. Ozawa, A. Hajitou, R. Rangel et al. An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumour microenvironment. Proceed. Nat. Acad. Sciences USA 106:2182-7, 2009 Papers in renowned magazines With T. Maack & M. Rabinovitch. Increase in ‘alkaline’ ribonuclease of rat kidney cortex after lysozyme and egg-white administration. Nature (London) 186:158, 1960 With M.M. Brentani & I. Raw. Messenger RNA activity of RNA purified from rat-liver nucleoli. Nature (London) 7: 687, 1966. With M.M. Brentani & I. Raw. Messenger activity of purified RNA from rat liver nuclei. Nature (London) 214:1122-1123, 1967 With H. Samaia, J.J. Mari, H.P. Vallada, R. Moura & A.J.G. Simpson. An Inherited Prion Disease With Prolonged Course And Psychiatric Onset. Nature (London) 390:241, 1997 PATENTS/INVENTIONS With L. L. Villa. Vetores de transferência molecular contendo a informação para a síntese de pro-insulina humana e seus processos de obtenção (1983) With S.J. de Souza. Isolated protein having molecular weight of from about 55 kilodaltons to about 65 kilodaltons (SDs-page) which binds to prion protein. US 5679530 (1997) With A.J.G. Simpson & E. Dias Neto. Method for determining nucleotide sequences using arbitrary primers and low stringency. US 0155438 (2002) With A.J. G. Simpson & E. Dias Neto. Métodos para determinar sistemas abertos para leitura do genoma de um organismo, para determinar que uma seqüência de nucleotídeos conhecida a partir de um genoma de um organismo corresponde a uma sequência de nucleotídeos a partir de um sistema aberto para leitura, para preparar uma molécula de ácido nuclêico contíguo a partir de um genoma de um organismo, e para sequenciar todo ou parte de um genoma de um organismo US 0919671620 (2002) PI9900267-1 A2 (2002)
Ricardo Bressani Castignoli
Ricardo Bressani Castignoli, Guatemalan food expert (Ciudad de Guatemala 28 September 1926 – Ciudad de Guatemala 30 January 2015) Authored over 500 publications between papers, monographs, book chapters and conference memoirs Discovered that certain coumponds found in soybean help digestive processes in man Developed cotton, legume, platan and cereal flours such as Incaparina (1959), Vitatol, Bienestarina and Innovarina Developed other food products like cookies HONOURS Babcock Hart Award, Institute of Food Technologists, USA (1970) McCollum Award, American Society of Clinical Nutrition (1971) Doctor Honoris Causa, Purdue University (1976) Albert Einstein World Award of Science, World Cultural Council (1984) Danone International Prize for Nutrition (2003) Guest Researcher, Rutgers State University & Massachusetts Institute of Technology
Ramchandra Kashinath Bhide
Ramchandra Kashinath Bhide, Indian economic botanist (fl.1912-35) SOME CONTRIBUTIONS With S.G. Bhalerao. The Kolamba rice of the North Konkan and its improvement by selection. India Dept. Agr. Mem. Bot. Ser. 14:199-245, 1927 With S. G. Bhalerao. Correlation studies in rice. Mem. Dept. Agric. Ind. 14(7):78-83, 1927 Inheritance and correlation of certain characters in rice crosses. Poona Agric. Col. Mag. 18:76-85, 1926 A cause of sterility in rice flowers. Agr. Jour. India 17:584-6, 1922 Two important problems in rice and how to solve them. Poona Agric. Coll. Mag. 11:33-6, 1919 Preliminary note on the study of the rice varieties. Poona Agr. Col. Mag. 5:286-90, 1914 DESCRIBED PLANTAE SPECIES (1912) Chloris quinquesetica Danthonidium gammiei Dichantium paranjpyeanus Enteropogon badamicus Sporobolus scabrifolius Tripogon roxburghianus HONORS Bhidea Stapf ex Bor 1948 (Poaceae)
Raj Chandra Bose
Raj Chandra Bose, Indian mathematician and statistician in United States (Hoshangabad, Madhya Pradesh 19 June 1901 – Fort Collins, Colorado 31 October 1987) Regarded as a founder of mathematical basis for experimental design With D.K. Ray-Chaudhuri and independent of Hocquenghem invented BCH codes (1960) With S.S. Shrikhande constructed a Greek-Latin square of size 10 disproving a 1782 Euler conjecture (1959) Introduced Bose-Mesner algebra (1959) With T. Shimamoto coined the term association scheme (1952) Invited Lecturer, International Congress of Mathematicians (1950) Eponym of Bose theorem (1934), Bose distribution (1935) and Bose-Burton theorem (1966)
Raimundo Braz Filho
Raimundo Braz de Souza Filho, Brazilian natural products chemist (Pacatuba, Ceará State 19 April 1935 – Obtained rufescidride, a new arylnaphthalene type lignan and the first containing an unusual anhydride moiety (2004) With C.R.S. Feitosa, R.C. Silva, J.E.S. A. Menezes et al. reported new ceramides for the first time in Cucurbitaceae (2011) With D. Oevstedal, T. Fossen, R.G. Oliveira Jr, A.P. Oliveira et al. isolated the first flavonoid from Bromeliaceae Family ((2014) DISCOVERED NEW COMPOUNDS (incomplete list) A new type of chalconoid dimers (2003) Darcyribeirine, a pentacyclic indole alkaloid (2002) Velloziolide, a diterpene with a novel skeleton (1982) Muscicapines, a class of guaiane-type sesquiterpene alkaloids (2005) Diploflavone, a flavonoid (2005) Trichotomol, a cadinenediol (2001) Hirtinone, a cycloartane-type triterpene (2013) Lepidotrichilins, protolimonoids (2013) Maytensifolone, a triterpene (2013) Aplysfistularine, a dibromotyrosine derivative (2012) Palyosulfonoceramides, sulfonylated ceramides from zoanthids (2012) Simiranes, diterpenes (2011) Pungecine, tropane alkaloid (2010) Spruceanumines, plumeram indole alkaloids (2009) Cymosamine, a C19 quassinoid (2005) Bowdichinia, a diaga-adamantane alkaloid (2004) Bowdenol, 2,3-dihydrobenfuran (2001) 7-epiclusanone, tetraprenylated benzaphenone (1999) Glaziovianol, terpenoid hydroquinone (1999) Botocudorol, bisabolene type nor-sesquiterpene (1991) Vismiaefolic acid, triterpene (1990) Sonderianin, furanoid diterpene (1981) Compactone, diterpenoid (1979) Laevigatin, sequiterpenoid (1978) Porosin, neolignan (1973) With W.B. Eyton. O.R. Gottlieb & M. T. Magalhães. A química de leguminosas brasileiras. XII. As apuleínas, flavona-hepta oxigenadas da Apuleia leiocarpa. An. Acad. Bras. Cien. 40(1):23-7, 1968 DEVELOPED PROCESSES/TECHNIQUES Improved an electrophic aromatic thallation of phenol ethers (1986) With T.C.A.B. Leal, S.P. Freitas & J.F. Silva. Simplified laboratory extraction of lemongrass essential oil by steam distillation. Ceres 48:717-22, 2001 With M. Faccione, D.T. Ferreira, H.O. Saradakis et al. A new method for asperphenamate synthesis and its antimicrobial activity evaluation. Natural Product Reports 20:537-41, 2006 BRAZILIAN PATENTS With H.S. Abreu. Isolation method of nor-triterpene from Lophanthera lactescens presenting pharmacological activity. Number 04007 (1999) HONOURS International Award of Recognition, American Biographical Institute (1995) International Cultural Diploma of Honor, American Biographical Institute (1995) International Leader in Achievement, International Biographical Centre, Cambridge (1995)
Rafael Barahona Andrade
Rafael Barahona Andrade, Ecuadorian physician and surgeon (Quito 30 September 1827 – Quito 01 March 1898) ACHIEVEMENTS Created Barahona draught (tonic) and Indian draught (against paludism). Devised a continuous extension and counterextension apparatus for femur fractures (1853). This apparatus arrived France in 1894 where was commended highly by Paul Jules Tillaux. See http://www.diccionariobiograficoecuador.com/tomos/tomo14/b3.htm (in Spanish)