Wilmar Dias da Silva, Brazilian immunologist (Barbacena, Minas Gerais State 12 October 1930 –

With I. Mota demonstrated that in low concentration of anti-histamine substances inhibit their release by mast cells and in high concentration occur the inverse (1960)

With I. Mota First to show anaphylactic antibodies fixed to mast cells (1960)

With I. Mota Showed that anaphylactic antibodies perform reactions only after binding to surface receptors on mast cells

With O. Bier, I. Mota & N. Vaz, authored Imunologia Básica e Aplicada (Fundamentals of Immunology), translated into English and German (1973) 

Proposed that anaphylatoxins rise from interactions between mast cells-polysaccharides-glycoproteins and complement system

With I. Lepow discovered, isolated and purified anaphylatoxin C3a and identified its role (1967)

With colleagues contributed to definite characterization of complement system like a main biological system and not a secondary reagent

With colleagues identified complement system as key element in infection control by Schistosoma mansoni

Demonstrated that Ig Y antibodies are potentially an efficient and low cost reagent for inclusion in immunodiagnostic kits

DEVELOPED METHODS/PROCESSES

With M.F.D. Furtado & G.M.D.D. Colletto. Controle de qualidade dos venenos animais e dos correspondentes antivenenos. I. Padronização dos métodos de ensaio das atividades bioquímicas e farmacológicas dos venenos de algumas espécies do gênero Bothrops e Crotalus usando amostras secas a temperatura ambiente ou liofilizada. Mem. Inst. Butantan 53(2):149-59, 1991  

With A.C.M. Rocha Campos, M.C.W. de Freitas, I.K. Yamaguchi & J.R. Marcelino. A sensitive and specific immunoassay for the measurement of the antibodies present in horse antivenoms endowed with the capacity to block the phospholipase A2-dependent hemolysis induced by snake venoms. J. Venom. Animal Toxins, 2(2):106-20, 1996.

With A.C.M.R.Campos; L.R.C.Gonçalves; M.C.C. Souza e Silva; H.G.Higashi,; I.K.Yamaguchi; A.C. Duarte & E.M.A. Kelen. Development of an antivenom against toxins of Lonomia obliqua caterpillars. Toxicon, 34(9):1045-9,1996.

With C.M.C. Almeida, M. M. Kanashiro, F.B.Rangel Filho, M.F.R. Matta & T.L. Kipnis. Development of snake antivenom in chicken and its recovery from the yolk as therapeutic tool for domestic animals. VeterinaryRecord, 143:579-84,1998.

With D.G. da Rocha, L.P. Sentinelli & T.L. Kipnis. Development of process to produce IgY antibodies to snake African venoms. Toxicon, 52: 293 -301, 2008

With C.M.C. de Almeida, A. Schiefer, M. Barral–Netto et al. Egg Yolk Anti-BfpA as a Tool for Recognizing and Identifying Enterophatogenic Escherichia coli. Scand. J. Immunol. 57: 573-81, 2003

With C.M.C. de Almeida, C.L. da Silva, H. Pena-Couto, T.L. Kipnis TL et al. Development of process to produce polyvalent IgY antibodies anti-African snake venom. Toxicon 52: 293-301, 2008.

With R. Guidolin, J.R. Marcelino, H.H. Gondo, T.L. Kipnis, C.L. da Silva et al. Development of Process to Produce Polyvalent Horse F(ab`)2 Antibodies Anti-African snake venom. African J Biotechnology, 9:2446-2455, 2010.

Developed 3 processes involving production and utilization of IgY antibodies (1988, 2003 & 2010)

With I. Gondo & R. Guidolin developed an immunization scheme of horses for antivenins production (1985)

LINKS

http://www.pgimunousp.com.br/sobre-nos/orientadores-e-linhas-de-pesquisa/dr-wilmar-dias-da-silva/ (in Portuguese)